缺氧诱导因子-1与心肌缺血再灌注损伤机制的研究进展  

Research Progress of Hypoxia-inducible Factor-1 and Mechanism of Myocardial Ischemia-reperfusion Injury

作　　者：赵远秦 宋颖楠 梁贵友 ZHAO Yuanqin;SONG Yingnan;LIANG Guiyou(Guizhou Medical University,Guiyang 550001,China;Translational Medicine Research Center of Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]贵州医科大学,贵阳550001 [2]贵州医科大学转化医学研究中心,贵阳550025

出　　处：《医学综述》2022年第15期2969-2974,共6页Medical Recapitulate

基　　金：国家自然科学基金(81560058,81960051)。

摘　　要：心肌缺血再灌注损伤(MIRI)是心血管外科体外循环术后患者发生心功能障碍或严重并发症的主要原因。MIRI的发病机制复杂,可能涉及心肌胰岛素抵抗、氧化应激、钙超载、细胞凋亡和炎症细胞浸润等。缺氧诱导因子-1(HIF-1)是由HIF-1α和HIF-1β共同构成的异源二聚体,其中HIF-1α是HIF-1发挥作用的主要因子。在缺氧条件下,心肌HIF-1表达上调并通过多种途径发挥心肌保护作用,但其在MIRI中的作用机制目前尚未明确,仍需未来进一步研究阐明。Myocardial ischemia-reperfusion injury(MIRI)is the main cause of cardiac dysfunction or serious complications after cardiopulmonary bypass.The pathogenesis of MIRI is complex and may involve myocardial insulin resistance,oxidative stress,calcium overload,apoptosis and inflammatory cell infiltration.Hypoxia-inducible factor 1(HIF-1)is a heterodimer composed of HIF-1αsubunit and HIF-1βsubunit,in which HIF-1αis the main factor of HIF-1 action.Under hypoxia,myocardial HIF-1 expression is upregulated and plays a myocardium protective role through a variety of ways.However,its mechanism in MIRI is still unclear and needs further study to clarify.

关 键 词：心肌缺血再灌注损伤 缺氧诱导因子1 体外循环 胰岛素抵抗 氧化应激 

分 类 号：R654.2[医药卫生—外科学]