中医禁食疗法对超重/肥胖2型糖尿病患者的临床疗效  

Clinical Effects of Chinese Medicine Fasting Therapy in Overweight/Obese Type 2 Diabetes Patients

作　　者：张汀滢 刘桃丽 胡建国[1] 张丽[1] 叶智裕 李志铃 陈洪达 秦鉴[1] ZHANG Ting-ying;LIU Tao-li;HU Jian-guo;ZHANG Li;YE Zhi-yu;LI Zhi-ling;CHEN Hong-da;QIN Jian(Department of Traditional Chinese Medicine,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107,China)

机构地区：[1]中山大学附属第七医院中医科,广东深圳518107

出　　处：《中山大学学报（医学科学版）》2022年第4期613-620,共8页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81874498);深圳市卫生系统临床研究项目(SZLY2018002);广州市科技计划项目(201903010044)。

摘　　要：【目的】探讨中医禁食疗法对超重/肥胖2型糖尿病患者的临床疗效。【方法】本研究以超重/肥胖2型糖尿病患者为研究对象,使用中医禁食疗法治疗1周,对所有患者的临床疗效进行评估并随访6月。在禁食结束、禁食后3月、6月分别对糖化血红蛋白、空腹血糖、空腹胰岛素、HOMA-IR、体质量、BMI等指标进行检测。【结果】完成中医禁食疗法后随访3月和随访6月时,患者糖化血红蛋白均显著低于基线值水平(P<0.001),空腹血糖在禁食后显著降低(P<0.001),HOMA-IR、体质量、BMI在禁食后、随访3月和随访6月均显著降低(P<0.05),腰围、腰臀比、体脂率禁食后显著降低(P<0.05)。【结论】中医禁食疗法可明显降低超重/肥胖2型糖尿病患者血糖水平,改善胰岛素抵抗,且在6个月的随访期内效果持续,同时对体质量、BMI、腰围、腰臀比、体脂率具有显著疗效,具备一定的安全性。【Objective】To investigate the curative effect of Chinese medicine fasting therapy in overweight/obese type 2 diabetes patients.【Methods】In this study,overweight/obese patients with type 2 diabetes were treated with Chinese medi⁃cine fasting therapy for 1 week.The clinical efficacy of all patients was evaluated and followed up for 6 months.Glycosylated hemoglobin,fasting plasma glucose,fasting insulin,HOMA-IR,weight,BMI and other indicators were tested at the end of the fasting,3 months and 6 months after the fasting.【Results】Glycosylated hemoglobin was significantly lower at 3 months and 6 months of follow-up than that at baseline(P<0.001).Fasting plasma glucose was significantly lower after fasting than baseline values(P<0.001),HOMA-IR,weight and BMI were significantly lower after fasting,at 3 months and 6 months of follow-up than that of baseline(P<0.05).Body fat rate,waist circumference and waist-to-hip ratio significantly decreased after fasting(P<0.05).【Conclusion】Chinese medicine fasting therapy can significantly reduce the blood glucose level of over⁃weight/obese type 2 diabetes patients,improving insulin resistance,and the effect will continue during the 6-month follow-up period;it can also reduce body weight,BMI,waist circumference,waist-to-hip ratio and body fat rate with safety.

关 键 词：中医禁食疗法 热量限制 超重/肥胖 2型糖尿病 

分 类 号：R247.1[医药卫生—中医临床基础]