HBV疫苗接种后机体T细胞应答和TCR CDR3受体库特征的研究进展  

Research Progress on T cell response and TCR CDR3 receptor repertoire characteristics after HBV vaccination

作　　者：陈剑霞 张婷 贺晓燕 姚新生 CHEN Jian-xia;ZHANG Ting;HE Xiao-yan;YAO Xin-sheng(Department of Immunology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学免疫学教研室,遵义563000

出　　处：《现代免疫学》2022年第3期259-263,共5页Current Immunology

基　　金：国家自然科学基金(81860300,82030307);贵州省百层次人才基金([2018]5637)。

摘　　要：接种HBV疫苗诱导机体免疫应答,产生保护性的HBsAb是预防HBV感染最重要的措施。T细胞在HBV疫苗应答过程中发挥极为重要的作用,这与个体HBsAb滴度的水平密切相关。该文就T细胞对HBV疫苗的应答以及形成的T细胞受体互补决定区3(T cell receptor complementarity determining region 3,TCR CDR3)受体库特征的研究概况和进展进行综述。Inoculation of HBV vaccine induces body's immune response.The production of protective HBsAb is essential in preventing HBV infection.T cells respond to the HBV vaccine and play an extremely important role in immune response and are highly correlated with the level of individual HBsAb titers.This review outlines the research progress of T cell response to HBV vaccine and the characteristics of the T cell receptor complementarity determining region 3(TCR CDR3)receptor repertoire.

关 键 词：乙型肝炎病毒疫苗 免疫接种 应答 T细胞 T细胞受体互补决定区3受体库 

分 类 号：R392.11[医药卫生—免疫学]