七氟烷对海马神经元凋亡相关信号通路影响的研究进展  

Research progress on effects of sevoflurane on apoptosis related signal pathways of hippocampal neurons

作　　者：谢云帆 刘咪 田毅[1] XIE Yunfan;LIU Mi;TIAN Yi(Department of Anesthesiology,Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院麻醉科,570208

出　　处：《天津医药》2022年第8期892-896,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81660195);海南省自然科学基金资助项目(821RC724)。

摘　　要：七氟烷是一种广泛使用的吸入性麻醉药,其对于认知功能的影响日益受到关注。该药可造成神经毒性,导致神经元损伤、凋亡和认知功能障碍。神经元凋亡途径包括内源性凋亡途径、外源性凋亡途径以及内质网途径,而凋亡相关信号通路在其中发挥重要作用,如磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K/Akt)、核因子κB(NF-κB)和丝裂原活化蛋白激酶(MAPK)等信号通路。对七氟烷引起海马神经细胞凋亡中的可能相关信号通路进行综述。Sevoflurane is a widely used inhalation anesthetic,and there is growing concern about its effects on cognitive function.Sevoflurane can cause neurotoxicity,resulting in neuronal damage,apoptosis and cognitive dysfunction.Neuronal apoptotic pathways include the endogenous apoptotic pathway,the exogenous apoptotic pathway and the endoplasmic reticulum pathway.Apoptosis-related signaling pathways,such as phosphatidylinositol-3-kinase/protein kinase B(PI3K/Akt),nuclear factor-κB(NF-κB)and mitogen-activated protein kinase(MAPK),play an important role in these pathways.This paper reviews the recent literature in this field and provides a review of the possible signaling pathways involved in sevoflurane-induced apoptosis in hippocampal neuronal cells.

关 键 词：七氟烷 细胞凋亡 海马 信号通路 综述 

分 类 号：R614[医药卫生—麻醉学]