检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:WANG Jie ZHANG Qi Astrid Lissette BARRETO SANCHEZ ZHU Bo WANG Qiao ZHENG Mai-qing LI Qing-he CUI Huan-xian WEN Jie ZHAO Gui-ping
出 处:《Journal of Integrative Agriculture》2022年第8期2372-2383,共12页农业科学学报(英文版)
基 金:supported by the grants from the National Natural Science Foundation of China(32072708);the National Key R&D Program of China(2018YFE0128000);the Major Scientific Research Projects of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202005)。
摘 要:Salmonella is one of the most common food-borne pathogens and its resistance in chicken can be improved through genetic selection.The heterophils/lymphocytes(H/L)ratio in the blood reflects the immune system status of chicken.We compared the genome data and spleen transcriptomes between the H/L ratio-selected and non-selected chickens,after Salmonella infection,aiming to identify the key genes participating in the antibacterial activity in the spleen.The results revealed that,the selected population had stronger(P<0.05)liver resistance to Salmonella typhimurium(ST)than the non-selected population.In the selected and non-selected lines,the identified differentiation genes encode proteins involved in biological processes or metabolic pathways that included the TGF-beta signaling pathway,FoxO signaling pathway,and Salmonella infection pathway.The results of the analysis of all identified differentially expressed genes(DEGs)of spleen revealed that the G protein-coupled receptor(GPCR)and insulin-like growth factor(IGF-I)signaling pathways were involved in the Salmonella infection pathway.Integrated analysis of DEGs and FST(fixation index),identified candidate genes involved in Salmonella infection pathway,such as GPR39,NTRK2,and ANXA1.The extensive genomic changes highlight the polygenic genetic of the immune response in these chicken populations.Numerous genes related to the immune performance are differentially expressed in the selected and non-selected lines and the selected lines has a higher resistance to Salmonella.
关 键 词:heterophils/lymphocytes selective sweep RNA-seq Salmonella typhimurium DISEASE-RESISTANCE
分 类 号:S858.31[农业科学—临床兽医学]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.15