KISS-1/KISS-1R系统在调控生殖内分泌系统的研究进展  

Research progress of KISS-1/KISS-1R system in regulating reproductive endocrine system

作　　者：黄田田 张雪荣 刘建忠 HUANG Tiantian;ZHANG Xuerong;LIU Jianzhong(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430061,China)

机构地区：[1]湖北中医药大学中医临床学院,湖北武汉430061

出　　处：《中国医药导报》2022年第20期33-36,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(81774280);湖北省自然科学基金项目(2020CFB825)。

摘　　要：KISS-1作为肿瘤转移抑制基因之一,最早在人类黑色素瘤中被发现,自发现之初便成为医学领域的研究热点。目前已经证实,KISS-1基因具有抑制肿瘤转移、调节促性腺激素释放激素分泌及作为食欲调节因子调控摄食行为等作用,因而被纳入恶性肿瘤、生殖系统及内分泌代谢等多系统疾病研究中。为此,本文主要从青春期启动、生殖功能、能量代谢等神经内分泌功能方面论述KISS-1的作用。As one of the tumor metastasis suppressors,KISS-1 is first discovered in human melanoma.KISS-1 has become a research hotspot in the medical field since its discovery.At present,KISS-1 has been proved to inhibit tumor metastasis,regulate gonadotrophin releasing hormone secretion,and regulate feeding behavior as an appetite regulator,so it has been included in the study of malignant tumors,reproductive system,endocrine,and metabolic diseases and other multi-system diseases.Therefore,this paper mainly discusses the effects of KISS-1 from the aspects of puberty initiation,reproductive function,energy metabolism,and other neuroendocrine functions.

关 键 词：KISS-1/KISS-1R 青春期启动 生殖内分泌功能 性早熟 

分 类 号：R585[医药卫生—内分泌]