广西低龄与高龄老年人体格相关指标与血糖、血压指标的相关性分析  

Correlation analysis of physical indicators with fasting plasma glucose and blood pressure indicators in low-aged and high-aged elderly people in Guangxi

作　　者：王钊平 倪晓琳 高丹妮 孙亮[1] 朱小泉[1] 焦娟 周起 杨泽[1] 原慧萍[1] Wang Zhaoping;Ni Xiaolin;Gao Danni;Sun Liang;Zhu Xiaoquan;Jiao Juan;Zhou Qi;Yang Ze;Yuan Huiping(The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Hospital/National Center of Gerontology of National Health Commission Beijing 100730,China;Peking University Fifth School of Clinical Medicine(Beijing Hospital),Beijing 100730,China;Department of Laboratory Medicine,the Seventh Medical Center,PLA General Hospital,Beijing 100700,China)

机构地区：[1]北京医院,国家老年医学中心,国家卫生健康委北京老年医学研究所,国家卫生健康委老年医学重点实验室,中国医学科学院老年医学研究院,北京100730 [2]北京大学医学部第五临床医学院,北京100730 [3]中国人民解放军总医院第七医学中心检验科,北京100700

出　　处：《中华老年医学杂志》2022年第7期843-848,共6页Chinese Journal of Geriatrics

基　　金：国家重点研发计划重点专项项目(2018YFC2000400);国家自然科学基金(81870552、81400790)。

摘　　要：目的分析低龄和高龄老年人体格相关指标与血压和空腹血糖水平的相关性。方法基于广西自然人群队列中筛选出1516名(65~110岁)为研究对象,采用横断面研究方法,分别检测体质指数(BMI)、腰围(WC)、腰高比(WHtR)、空腹血糖(FPG)和血压,并对其关联性进行分析。结果超重老年人和超重低龄老年人组与BMI正常的老年人和低龄老年人组相比,其患高血压合并空腹血糖受损的风险均增加(OR=2.66,95%CI:1.90~3.72;OR=3.03,95%CI:2.11~4.34),一般肥胖老年人和一般肥胖低龄老年人组患高血压(OR=5.25,95%CI:2.07~13.28;OR=4.75,95%CI:1.84~12.21)、空腹血糖受损(OR=2.95,95%CI:1.00~8.69;OR=3.06,95%CI:1.04~9.02)以及患高血压合并空腹血糖受损(OR=7.94,95%CI:3.04~20.72;OR=8.68,95%CI:3.28~22.94)的风险均增加,过轻的低龄老年人组患高血压的风险降低(OR=0.27,95%CI:0.09~0.80);中心性肥胖组(WC)老年人与非中心性肥胖组老年人相比,其患高血压(OR=1.39,95%CI:1.04~1.84)、高血压合并空腹血糖受损(OR=2.39,95%CI:1.75~3.27)的风险增加,中心性肥胖低龄老年人组患高血压(OR=1.46,95%CI:1.07~2.00)、空腹血糖受损(OR=1.62,95%CI:1.14~2.28)以及患高血压合并空腹血糖受损(OR=3.03,95%CI:2.13~4.32)的风险均增加;中心性肥胖组(WHtR)老年人与低龄老年人组患高血压(OR=1.35,95%CI:1.03~1.76;OR=1.55,95%CI:1.13~2.14)、空腹血糖受损(OR=1.42,95%CI:1.04~1.94;OR=1.62,95%CI:1.13~2.31)以及患高血压合并空腹血糖受损(OR=2.20,95%CI:1.60~3.02;OR=3.22,95%CI:2.14~4.84)的风险均增加。高龄老年人组中,BMI与舒张压相关;且WHtR与空腹血糖水平具有相关性。结论广西壮族自治区老年人群的血压和空腹血糖水平随体格相关指标(BMI、WC、WHtR)的升高而升高,一般性肥胖和中心性肥胖的老年患者患高血压、空腹血糖受损以及高血压合并空腹血糖受损的风险明显增加,其中低龄老年患者的患病风险更高。Objective To analyze the relationship between physical indicators and blood pressure or fasting plasma glucose levels in the young-old and oldest-old.Methods Totally 1516 subjects from the Guangxi Natural Longevity Cohort were screened in this study and physical examination parameters included body mass index(BMI),waist circumference(WC),waist-to-height ratio(WHtR),fasting plasma glucose(FPG)and blood pressure,and the correlations between them were analyzed.Results The overweight elderly and overweight young elderly groups had an increased risk of concurrent hypertension and impaired fasting glucose,compared with both elderly people with normal BMI and young elderly people with normal BMI(OR=2.66,95%CI:1.90-3.72;OR=3.03,95%CI:2.11-4.34).Elderly people with general obesity and young elderly people with general obesity were more likely to have hypertension(OR=5.25,95%CI:2.07-13.28;OR=4.75,95%CI:1.84-12.21),impaired fasting glucose(OR=2.95,95%CI:1.00-8.69;OR=3.06,95%CI:1.04-9.02),and concurrent hypertension and impaired fasting glucose(OR=7.94,95%CI:3.04-20.72;OR=8.68,95%CI:3.28-22.94),whereas underweight young elderly had a reduced risk of hypertension(OR=0.27,95%CI:0.09-0.80).Elderly people in the central obesity group(WC)showed increased risk of hypertension(OR=1.39,95%CI:1.04-1.84)and concurrent hypertension and impaired fasting glucose(OR=2.39,95%CI:1.75-3.27),compared with those in the non-central obesity group.Young elderly people with central obesity had increased risk of hypertension(OR=1.46,95%CI:1.07-2.00),impaired fasting glucose(OR=1.62,95%CI:1.14-2.28),and concurrent hypertension and impaired fasting glucose(OR=3.03,95%CI:2.13-4.32);both elderly people and young elderly people in the central obesity group(WHtR)had increased risk of hypertension(OR=1.35,95%CI:1.03-1.76;OR=1.55,95%CI:1.13-2.14),impaired fasting glucose(OR=1.42,95%CI:1.04-1.94;OR=1.62,95%CI:1.13-2.31),and concurrent hypertension and impaired fasting glucose(OR=2.20,95%CI:1.60-3.02;OR=3.22,95%CI:2.14-4.84).In the elderly group,BMI was corr

关 键 词：中心性肥胖 空腹血糖受损 高血压 

分 类 号：R195[医药卫生—卫生统计学]