高毒力肺炎克雷伯菌的研究进展  

Research progress of hypervirulent Klebsiella pneumonia

作　　者：岳娜[1] 张晓方 胡志东[1] Yue Na;Zhang Xiaofang;Hu Zhidong(Clinical Laboratory,Tianjin Medical University General Hospital,Tianjin 300070,China)

机构地区：[1]天津医科大学总医院医学检验科,天津300070

出　　处：《国际流行病学传染病学杂志》2022年第3期204-207,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家自然科学基金(81402391)。

摘　　要：高毒力肺炎克雷伯菌(hvKP)具有较高毒力及高黏液性,易造成健康宿主感染,以肝脓肿最为常见,并引发多部位侵袭性感染及血流感染。目前耐药hvKP相关菌株,尤其是耐碳青霉烯类高毒力肺炎克雷伯菌(CR-hvKP)的出现,给临床诊疗带来更大的挑战。本文从hvKP的流行现状、毒力因子、耐药机制及其感染治疗等方面进行综述。Hypervirulent Klebsiella pneumoniae(hvKP)is highly virulent and mucinous,and often causes infection in healthy hosts.Liver abscess is the most common infection,which can easily lead to multi-site invasive infection and bloodstream infection.At present,the emergence of drug-resistant hvKP-related strains,especially carbapenem-resistant hypervirulent Klebsiella pneumoniae(CR-hvKP),has brought greater challenges to clinical diagnosis and treatment.In this paper,the epidemic status,virulence factors,drug resistance mechanism and infection treatment of hvKP are reviewed.

关 键 词：肺炎克雷伯菌 毒力因子 高黏液性 耐药性 

分 类 号：R378[医药卫生—病原生物学]