GSDMD介导的细胞焦亡在糖尿病慢性并发症中的作用研究进展  

Research progress in effect of GSDMD-mediated pyroptosis on chronic complications of diabetes mellitus

作　　者：左玲凤 郭志新[1] ZUO Ling-feng;GUO Zhi-xin(Department of Endocrinology,The Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第二医院内分泌科,山西太原030001

出　　处：《中国临床研究》2022年第7期952-956,共5页Chinese Journal of Clinical Research

基　　金：山西省回国留学人员科研资助项目(2020-192);山西省基础研究计划项目(自然科学研究面上项目)(202103021224414)。

摘　　要：细胞焦亡是指由Gasdermiu D(GSDMD)介导的炎症性细胞死亡,炎症小体激活后,活化的caspase-1/4/5/11剪切共同的底物GSDMD,促进了炎性物质的释放。细胞焦亡通过炎症的级联反应在糖尿病及其并发症的发生发展中起重要作用。一些潜在的靶向细胞焦亡和炎性体信号通路的分子可能在不久的将来成为管理和治疗糖尿病及其并发症的新途径。本研究总结目前对细胞焦亡相关分子机制的认识,以及细胞焦亡在糖尿病并发症发展中的作用的最新进展。Pyroptosis is inflammatory cell death mediated by Gasdermin family,mainly mediated by Gasdermin D(GSDMD).Activated caspase-1/4/5/11 cuts common substrate GSDMD after activation of inflammasome,which promotes the release of inflammatory substances.Pyroptosis plays an important role in the development of diabetes mellitus and its complications through the cascade of inflammation.Some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future.This paper summarise the current understanding of the molecular mechanisms associated with pyroptosis,as well as recent advances in the role of pyroptosis in the development of diabetic complications.

关 键 词：细胞焦亡 Gasdermiu D 糖尿病 慢性并发症 半胱氨酸蛋白酶 炎症小体 

分 类 号：R587.2[医药卫生—内分泌]