血清HBsAg水平、HBV-DNA载量与乙肝后肝纤维化程度的相关性分析  

Correlation analysis of serum HBsAg level,HBV-DNA load and liver fibrosis after hepatitis B

作　　者：李长安[1] 刘春秀[1] 谢晓娟 LI Changan;LIU Chunxiu;XIE Xiaojuan(Infection Department,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,China)

机构地区：[1]新乡医学院第三附属医院感染科,河南新乡453000

出　　处：《临床医学研究与实践》2022年第23期9-11,共3页Clinical Research and Practice

基　　金：国家科技重大专项课题(No.2017ZX10203202-005)。

摘　　要：目的探讨慢性乙型肝炎(CHB)患者血清乙肝表面抗原(HBsAg)水平、乙肝病毒DNA(HBV-DNA)载量与乙肝后肝纤维化程度的相关性。方法选择2018年2月至2020年5月我院收治的560例CHB患者,均检测血清HBsAg水平、HBV-DNA载量和肝纤维化指标,并判断CHB患者肝纤维化程度。分析HBsAg水平、HBV-DNA载量、肝硬度值、肝纤维化指标与肝纤维化程度的相关性,HBsAg水平与HBV-DNA载量、肝纤维化指标的相关性,HBV-DNA载量与肝纤维化指标的相关性。结果HBsAg水平随肝纤维化严重程度加重而降低,肝硬度值与Ⅲ型前胶原肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、层粘连蛋白(LN)水平随肝纤维化严重程度加重而升高(P<0.05)。HBsAg水平与肝纤维化程度呈负相关,肝硬度值、PCⅢ、Ⅳ-C、HA、LN水平与肝纤维化程度呈正相关(P<0.05)。HBsAg水平与PCⅢ和Ⅳ-C水平不存在直线相关性关系,但HBV-DNA载量与及HA、LN水平呈正相关(P<0.05)。HBV-DNA载量与Ⅳ-C水平不存在相关性,但与PCⅢ、HA和LN水平呈正相关(P<0.05)。结论HBsAg水平、HBV-DNA载量均与CHB肝纤维化在一定程度上具备相关性,可用于检测患者肝纤维化情况。Objective To investigate the correlation between serum hepatitis B surface antigen(HBsAg)level and hepatitis B virus DNA(HBV-DNA)load in patients with chronic hepatitis B(CHB)and the degree of liver fibrosis after hepatitis B.Methods Five hundred and sixty CHB patients admitted in our hospital from February 2018 to May 2020 were selected to detect serum HBsAg level,HBV-DNA load and liver fibrosis indexes,and the degree of liver fibrosis in CHB patients was estimated.The correlation between HBsAg level,HBV-DNA load,liver hardness value,liver fibrosis indicators and the degree of liver fibrosis,the correlation between HBsAg level and HBV-DNA load,liver fibrosis indicators,and the correlation between HBV-DNA load and liver fibrosis indicators were analyzed.Results The level of HBsAg decreased with the aggravation of liver fibrosis,and the liver hardness value and the levels of procollagenⅢ(PCⅢ),typeⅣcollagen(Ⅳ-C),hyaluronic acid(HA),laminin(LN)increased with the aggravation of liver fibrosis(P<0.05).HBsAg level was negatively correlated with the degree of liver fibrosis,and liver hardness value,PCⅢ,Ⅳ-C,HA,LN levels were positively correlated with degree of liver fibrosis(P<0.05).There was no linear correlation between HBsAg level and PCⅢandⅣ-C levels,but it was positively correlated with HBV-DNA load and HA,LN levels(P<0.05).There was no correlation between HBV-DNA load andⅣ-C level,but it was positively correlated with PCⅢ,HA and LN levels(P<0.05).Conclusion HBsAg level and HBV-DNA load are correlated with CHB liver fibrosis to some extent,which can be used to detect liver fibrosis in patients.

关 键 词：慢性乙型肝炎 乙型肝炎病毒 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]