基于eICU合作研究数据库分析系统免疫炎症指数对急性肺栓塞患者短期预后的预测价值  

Analysis of predictive value of systemic immune-inflammation index for short-term prognosis of patients with acute pulmonary embolism based on eICU cooperative research database

作　　者：张薇[1] 王贵佐[1] 王少纯 杜洁[2] ZHANG Wei;WANG Guizuo;WANG Shaochun;DU Jie(No.1 Respiratory and Critical Care Medicine Department,Shaanxi Provincial People's Hospital,Xi'an 710003,China;Medical Examination Center,Shaanxi Provincial People's Hospital,Xi'an 710003,China)

机构地区：[1]陕西省人民医院呼吸与危重症一科,陕西西安710003 [2]陕西省人民医院体检中心,陕西西安710003

出　　处：《临床医学研究与实践》2022年第23期12-14,共3页Clinical Research and Practice

基　　金：陕西省自然科学基础研究计划项目(No.2021JQ-907)。

摘　　要：目的探讨系统免疫炎症指数(SII)对急性肺栓塞(APE)患者短期预后的预测价值。方法回顾性分析急诊重症监护室(eICU)合作研究数据库中2014—2015年入住重症监护室(ICU)、诊断为APE患者的临床数据。应用受试者工作(ROC)曲线和多因素Logistic回归分析分别评估SII对APE患者院内死亡的预测价值及其关系。结果本研究共纳入859例患者,其中院内死亡41例(4.77%)。与院内存活组相比,院内死亡组的年龄更大,恶性肿瘤、机械通气占比、急性生理学及慢性健康状况评分系统Ⅳ(APACHEⅣ)评分及SII更高(P<0.05)。SII预测APE患者院内死亡的ROC曲线下面积为0.709(95%CI 0.631~0.786)。多因素Logistic回归分析结果显示,机械通气、APACHEⅣ评分和SII为影响APE患者院内死亡的独立危险因素(P<0.05)。结论SII是APE患者院内死亡的独立危险因素,可评估患者的短期预后。Objective To explore the predictive value of systemic immune-inflammation index(SII)for the short-term prognosis of patients with acute pulmonary embolism(APE).Methods The clinical data of APE patients admitted in intensive care unit(ICU)from 2014 to 2015 in the emergency intensive care unit(eICU)cooperative research database were analyzed retrospectively.Predictive value of SII for in-hospital death in APE patients and its relationship were evaluated by receiver operating characteristic(ROC)curve and multivariate Logistic regression analysis.Results A total of 859 patients were included in this study,including 41 cases(4.77%)of in-hospital death.Compared with the in-hospital survival group,the age of the in-hospital death group was older,and the propoftion of malignant tumor and mechanical ventilation,acute physiology and chronic health evaluationⅣ(APACHEⅣ)score and SII were higher(P<0.05).The area under the ROC curve of SII predicting the in-hospital death of APE patients was 0.709(95%CI 0.631-0.786).The multivariable Logistic regression analysis results showed that mechanical ventilation,APACHEⅣscore and SII were independent risk factors for in-hospital death in APE patients(P<0.05).Conclusion SII is an independent risk factor for in-hospital death in APE patients,which can evaluate the short-term prognosis of patients.

关 键 词：急性肺栓塞 院内死亡 系统免疫炎症指数 急诊重症监护室 

分 类 号：R563.5[医药卫生—呼吸系统]