嗜酸性粒细胞哮喘的研究进展  

Research progress on eosinophilic asthma

作　　者：林慧敏 符昱 方章福 谢佳星 Lin Huimin;Fu Yu;Fang Zhangfu;Xie Jiaxing(State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou 510120,China;Department of Respirology and Allergy,Third Affiliated Hospital of Shenzhen University,Shenzhen 518020,China;Department of Respiratory and Critical Care Medicine,Yangjiang People’s Hospital,Yangjiang 529500,China)

机构地区：[1]国家呼吸系统疾病临床医学研究中心/呼吸疾病国家重点实验室/广州呼吸健康研究院/广州医科大学第一附属医院/广州医科大学,广州510120 [2]深圳大学附属第三医院呼吸与过敏科,深圳518020 [3]广东省阳江市人民医院呼吸和危重病医学科,阳江529500

出　　处：《结核与肺部疾病杂志》2022年第4期328-333,共6页Journal of Tuberculosis and Lung Disease

基　　金：国家自然科学基金(82000024);呼吸疾病国家重点实验室开放课题(SKLRD-Z-202119)。

摘　　要：哮喘是临床常见的异质性慢性气道炎症性疾病,其中嗜酸性粒细胞哮喘(eosinophilic asthma,EA)是最常见的临床表型。持续性气道嗜酸性粒细胞炎症极易促使哮喘进展为重症,是导致哮喘高致残率及高致死率的原因之一。变应性EA与非变应性EA在临床特征、发病机制方面具有明显区别,深入认识EA发病机制对疾病的管理和改善患者预后具有重要意义。作者对EA的研究进展进行综述。Asthma is a heterogenous chronic airway inflammatory disease with various phenotypes,among which eosinophilic asthma(EA)is the most common one.Persistent eosinophilic airway inflammation may lead to severe asthma,and thus accounts for the high morbidity and mortality rates.Allergic EA and non-allergic EA subtypes varied significantly in terms of their clinical characteristics and pathogenesis.Recognizing pathogenic mechanism of EA is of great significance for disease management and for improving patient’s prognosis.In this review,we summarized the research progress on EA.

关 键 词：嗜酸粒细胞 哮喘 疾病特征 发病机制 诊断 

分 类 号：R562.25[医药卫生—呼吸系统]