基于还原氧化石墨烯的非纳西丁电化学检测  

Electrochemical sensing of phenacetin on electrochemically reduced graphene oxide modified glassy carbon electrode

作　　者：孟小桐 朱德京 姜宇航 曹悦 司维蒙 曹俊 李秋红[1] 李蛟[1] 雷武[2] MENG Xiao-tong;ZHU De-jing;JIANG Yu-hang;CAO Yue;SI Wei-meng;CAO Jun;LI Qiu-hong;LI Jiao;LEI Wu(School of Materials Science and Engineering,Shandong University of Technology,Zibo 255049,China;School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China)

机构地区：[1]山东理工大学材料科学与工程学院,山东淄博255000 [2]南京理工大学化学与化工学院,江苏南京210000

出　　处：《新型炭材料（中英文）》2022年第4期764-772,共9页New Carbon Materials

基　　金：国家自然科学基金(51502161,51572127,21576138,21706148);山东省自然科学基金(ZR2018BB038);山东省高等学校科技计划(J15LA08,J16LA07).

摘　　要：研究了非纳西丁在还原氧化石墨烯、氮掺杂石墨烯等材料表面的电化学氧化还原行为,证明了还原氧化石墨烯具有更好的电化学响应,体现为更高的电流响应和更低的氧化还原过电位。同时,通过电化学方法对非那西丁的氧化还原反应机理进行了推断,证明了非那西丁通过氧化反应生成了一种醌-亚胺阳离子的中间体,通过水解生成N-乙酰基-对-苯醌亚胺(NAPQI),经可逆的氧化还原反应实现NAPQI与对乙酰氨基酚的互相转化。基于还原氧化石墨烯修饰电极,对非那西丁进行了定量检测,检出限为0.91μmol L^(−1);证明了对乙酰氨基酚不会干扰对非那西丁的检测,但非那西丁经氧化还原反应产生的对乙酰氨基酚会影响对溶液中原本的对乙酰氨基酚的测定。It is known that the electrochemical determination of phenacetin,a widely used analgesic,is challenging because of the interference of the electroactive intermediate,acetaminophen.Phenacetin was proven to be electroactive in 1980s,but its electrochemical determination has not been widely reported.This determination on an electrochemically reduced graphene oxide(ERGO)electrode was investigated and compared with several nitrogen-doped graphene samples.Results indicate that ERGO has a higher current response and lower oxidation potential than nitrogen-doped graphene.An ERGO electrode as a phenacetin sensor has a detection limit of 0.91μmol L^(−1).The redox mechanism of phenacetin is inferred by electrochemical experiments,and the reactions under different pH values are proposed.Acetaminophen is considered to be the main intermediate and that does not interfere with the determination of phenacetin.But phenacetin obviously interferes with the response of acetaminophen,suggesting that the simultaneous detection of phenacetin and acetaminophen is not possible.Species such as Cu^(2+),Al^(3+),methanol,ethylene glycol,glucose,and ascorbic acid do not interfere with the determination of phenacetin.

关 键 词：非纳西丁 对乙酰氨基酚 电化学还原氧化石墨烯 电化学传感 

分 类 号：TQ127.11[化学工程—无机化工]