针灸调周法治疗肾虚肝郁型卵巢储备功能减退的临床效果  

Clinical therapeutic effects of acupuncture periodic therapy for diminished ovarian reserve of kidney-deficiency and liver-qi stagnation type

作　　者：章小娟 赵锐 陈阳 王菁 孙曌[2] 夏小焱 周璟 赵星 ZHANG Xiao-juan;ZHAO Rui;CHEN Yang;WANG Jing;SUN Zhao;XIA Xiao-yan;ZHOU Jing;ZHAO Xing(Department of Traditional Chinese Medicine,Hainan Women and Children′s Medical Center,Haikou 570206,Hainan,China;Teaching and Research Office of Acupuncture and Moxibustion,Hainan Medical University,Haikou 570102,Hainan,China;Reproductive Medicine Centre,Hainan Women and Children′s Medical Center,Haikou 570206,Hainan,China;Reproductive Medicine Centre,First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan,China)

机构地区：[1]海南省妇女儿童医学中心中医科,海南省海口市570206 [2]海南医学院针灸教研室,海南省海口市570102 [3]海南省妇女儿童医学中心生殖医学中心,海南省海口市570206 [4]海南医学院附属第一医院生殖医学中心,海南省海口市570102

出　　处：《广西医学》2022年第12期1352-1355,1383,共5页Guangxi Medical Journal

基　　金：海南省卫生健康行业科研项目(20A200177);海南省临床医学中心建设项目。

摘　　要：目的观察针灸调周法治疗肾虚肝郁型卵巢储备功能减退(DOR)的临床效果。方法将90例肾虚肝郁型DOR患者随机分为对照组和治疗组,每组45例。对照组采用西药周期疗法治疗,治疗组采用针灸调周法治疗,两组均治疗3个月经周期。观察两组治疗前后中医证候评分、血清性激素[卵泡刺激素(FSH)、黄体生成素(LH)、FSH/LH比值、雌二醇]水平、抗米勒管激素(AMH)水平及窦卵泡计数(AFC)。结果与治疗前比较,治疗后两组患者的中医证候评分、血清FSH和LH水平、FSH/LH比值均下降,血清雌二醇和AMH水平、AFC均升高,且治疗组上述指标均优于对照组(均P<0.05)。结论针灸调周法能更有效地改善肾虚肝郁型DOR患者的临床症状和血清性激素水平,促进卵巢内窦卵泡发育,提高患者卵巢储备功能。Objective To observe the clinical effects of acupuncture periodic therapy for treating diminished ovarian reserve(DOR)of kidney-deficiency and liver-qi stagnation type.Methods A total of 90 DOR patients with kidney-deficiency and liver-qi stagnation were randomly assigned to control group or treatment group,with 45 cases in each group.The control group was treated with periodic therapy of Western Medicine,whereas the treatment group was treated with acupuncture periodic therapy.The treatment of 3 menstrual cycles was given to both groups.The pre-and post-treatment Chinese Medicine Syndrome score,serum sex hormone levels(follicle stimulating hormone[FSH],luteinizing hormone[LH],FSH/LH ratio,estradiol),as well as anti-Müllerian hormone(AMH)level and antral follicle count(AFC)were observed in both groups.Results Compared with before treatment,the score of Chinese Medicine Syndrome,serum FSH and LH levels,and FSH/LH ratio were decreased in patients of the two groups after treatment,whereas serum estradiol and AMH levels,and AFC were increased,and the treatment group exhibited superior aforementioned indices to compared with the control group(all P<0.05).Conclusion Acupuncture periodic therapy can more effectively ameliorate the clinical symptoms and the levels of serum sex hormones of DOR patients of kidney-deficiency and liver-qi stagnation type,promote the development of the ovarian antral follicle,and improve the ovarian reserve function of patients.

关 键 词：卵巢储备功能减退 针灸调周法 月经周期 肾虚肝郁 

分 类 号：R711.75[医药卫生—妇产科学] R245[医药卫生—临床医学]