郑氏妇科1号方治疗慢性盆腔炎气滞血瘀型的疗效及对炎症因子水平的影响  

Efficacy of Zheng's gynecological No.1 formula for chronic pelvic inflammatory disease of Qi stagnation and blood stasis type and how to impact on inflammatory factors

作　　者：刘晓燕[1] 夏丽颖[1] 刘德慧 LIU Xiaoyan;XIA Liying;LIU Dehui(Department of Gynecology,Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800)

机构地区：[1]上海市嘉定区中医医院妇科,上海201800

出　　处：《河北中医》2022年第6期939-942,1001,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：上海市嘉定区科学技术委员会2019年嘉定区农业和社会事业科研项目(编号:JDKW-2019-W19)。

摘　　要：目的观察郑氏妇科1号方治疗慢性盆腔炎气滞血瘀型的疗效及对炎症因子水平的影响。方法将72例慢性盆腔炎气滞血瘀型患者按照随机数字表法分为2组,对照组36例予妇科千金胶囊治疗,治疗组36例予郑氏妇科1号方治疗,2组均治疗6周。比较2组疗效;比较2组治疗前后中医证候评分变化;比较2组治疗前后局部阳性体征评分变化;比较2组治疗前后疼痛视觉模拟评分(VAS)变化;比较2组治疗前后炎症因子变化;比较2组复发情况;比较2组不良反应发生情况。结果治疗组总有效率94.44%(34/36),对照组总有效率75.00%(27/36),治疗组疗效优于对照组(P<0.05)。2组治疗后下腹疼痛、腰骶部痠痛、带下量多、情志抑郁或烦躁、胸胁或乳房胀痛、经血量多有块、婚久不孕评分及总评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后子宫活动受限压痛、左侧附件增厚压痛、右侧附件增厚压痛、宫骶韧带增粗压痛评分及总评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后疼痛VAS均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)均较本组治疗前降低(P<0.05),IL-10较本组治疗前升高(P<0.05),且治疗后治疗组血清TNF-α、IL-6均低于对照组(P<0.05),IL-10高于对照组(P<0.05)。治疗组复发率7.41%(2/27),对照组复发率35.71%(5/14),治疗组远期疗效优于对照组(P<0.05)。结论郑氏妇科1号方治疗慢性盆腔炎气滞血瘀型,可缓解患者临床症状,提高生活质量,且安全无明显副作用,其机制可能与调节炎症因子水平有关。Objective To observe the efficacy of Zheng's gynecological No.1 formula for chronic pelvic inflammatory disease(CPID)of Qi stagnation and blood stasis type and how to impact on inflammatory factors.Methods Totally 72 CPID patients(Qi stagnation and blood stasis type)were randomly divided into the treatment group(n=36)and the control group(n=36).The control group was treated with Fuke Qianjin capsule(FKQJ),and the treatment group with Zheng's gynecological No.1 formula.A 6-week treatment were performed to compare traditional Chinese medicine(TCM)syndrome score,local positive physical sign scores,visual analogue score(VAS)for pain,inflammatory factors,recurrence rate;the curative effect and adverse reactions were assessed.Results The overall effective rate was 94.44%(34/36)in the treatment group,higher than that of 75.00%(27/36)in the control group(P<0.05).After treatment,scores of lower abdominal pain,lumbar and sacral pain,large amount of blood,depression or irritability,chest or breast pain,a lot of menstrual volume,long marriage infertility in groups were decreased(P<0.05),which were decreased in the treatment group compared with the control group(P<0.05);scores of pressure pain and activity limitation of uterine,thickening and tenderness of left accessory and right accessory,thickening and tenderness of uterosacral ligament in groups were decreased(P<0.05),the treatment group was more common(P<0.05);VAS for pain in groups was decreased(P<0.05),reduction in the treatment group was more prevalent(P<0.05);decreased serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and increased IL-10 were measured in groups after treatment(all P<0.05),lower TNF-α,IL-6,and higher IL-10 were detected in the treatment group than those in the control group(all P<0.05).Compared with the control group,recurrence rate in the treatment goups was decreased,long-term effect in the treatment goups was better(P<0.05).Conclusion For CPID patients(Qi stagnation and blood stasis type),Zheng's gynecological No.1 formula can relieve the

关 键 词：慢性病 盆腔炎性疾病 辨证 中药疗法 颗粒剂 

分 类 号：R711.33[医药卫生—妇产科学] R283.627[医药卫生—临床医学]