振腹推拿联合附件炎1号方热敷对输卵管积水患者体外受精-胚胎移植妊娠结局的影响  

Effect of abdominal-vibrating manipulation combined with annexitis prescription No.1 on pregnancy outcome of hydrosalpinx patient with in vitro fertilization-embryo transfer

作　　者：赵志斌 颜宏利 袁雪菲 ZHAO Zhibin;YAN Hongli;YUAN Xuefei(Department of Acupuncture and Tuina Science,Faculty of Traditional Chinese Medicine,Naval Medical University,Shanghai 200433;Department of reproductive medicine,First Affiliated Hospital of Naval Medical University,Shanghai 200433)

机构地区：[1]中国人民解放军海军军医大学中医系针灸推拿学教研室,上海200433 [2]中国人民解放军海军军医大学第一附属医院生殖医学中心,上海200433

出　　处：《河北中医》2022年第6期988-992,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划课题(编号:2018YFC1005002)。

摘　　要：目的观察振腹推拿联合附件炎1号方热敷对输卵管积水患者体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法将309例输卵管积水IVF-ET患者按照随机数字表法分为3组,治疗组141例在行IVF前予振腹推拿联合附件炎1号方热敷治疗,预处理对照组88例在体外受精(IVF)前对输卵管积水进行西医预处理治疗,未预处理对照组80例在IVF-ET前未接受任何治疗。比较治疗组治疗前后输卵管积水程度变化;比较3组临床助孕数据;比较3组妊娠结局及新生儿结局。结果治疗组治疗后输卵管积水程度较治疗前出现不同程度的减轻或消失(P<0.05)。治疗组人绒毛膜促性腺激素(HCG)日子宫内膜厚度、获卵数、成熟卵子(MII)期卵子数均高于预处理对照组、未预处理对照组(P<0.05);3组促性腺激素(Gn)总量、Gn总天数比较差异均无统计学意义(P>0.05);治疗组卵裂率、正常受精率、胚胎着床率、临床妊娠率均高于预处理对照组、未预处理对照组(P<0.05);治疗组周期取消移植率高于预处理对照组(P<0.05),低于未预处理对照组(P<0.05)。治疗组异位妊娠率、流产率均低于未预处理对照组(P<0.05),但与预处理对照组比较差异无统计学意义(P>0.05);治疗组胚胎停止发育率低于预处理对照组、未预处理对照组(P<0.05)。结论振腹推拿联合附件炎1号方热敷治疗输卵管积水IVF-ET,能改善患者输卵管积水程度,改善助孕数据,提高IVF-ET患者妊娠率,减少妊娠和新生儿不良结局。Objective To retrospectively analyze the effect of abdominal-vibrating manipulation combined with annexitis prescription No.1 on pregnancy outcome of hydrosalpinx patient underwent in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 309 hydrosalpinx patients underwent IVF-ET were randomly divided into 3 groups.Before IVF,the treatment group(n=141)was treated with abdominal-vibrating manipulation combined with annexitis prescription No.1,the control group(n=88)with Western medicine treatment,and the untreated control group(n=80)did not receive any treatment.The aim was to assess degree of hydrosalpinx,the data of IVF-assisted pregnancy,pregnancy outcomes and neonatal outcomes among the three groups.Results After treatment,the hydrosalpinx in the treatment group was relieved or disappeared(P<0.05).The endometrial thickness and the number of retrieved oocyte and in vitro matured(IVM-MII)oocytes on the day of human chorionic gonadotrophin(hCG)day in the treatment group were higher than the other two groups(P<0.05);there was no statistical difference in the total gonadotropin(Gn)and Gn days among the three groups(P<0.05).The cleavage rate,normal fertilization rate,embryo implantation rate and clinical pregnancy rate in the treatment group were the highest among the three groups(P<0.05);the cancellation rate in the untreated control group was most prevalent(P<0.05),followed by the treatment group(P<0.05)and the control group(P<0.05).The incidence of ectopic pregnancy and abortion in the treatment group were lower than those in the untreated control group(P<0.05),but there was no significant difference compared with the control group(P>0.05).The embryonic arrest in the treatment group was lower compared with the control group and the untreated control group(P<0.05).Conclusion For hydrosalpinx patient with IVF-ET,abdominal-vibrating manipulation combined with annexitis prescription No.1 can improve the degree of hydrosalpinx and assist pregnancy data,with improvement of pregnancy rate and reduction of pregn

关 键 词：输卵管疾病 胚胎组织移植 体外受精 推拿 穴位贴敷法 

分 类 号：R711.76[医药卫生—妇产科学] R321.2[医药卫生—临床医学] R244.1R245.9