丙种球蛋白辅助阿司匹林治疗小儿川崎病的临床效果观察  

Clinical Effect Observation of Gamma Globulin-Assisted Aspirin Treatment of Kawasaki Disease in Children

作　　者：刘馨 张莉[1] Liu Xin;Zhang Li(96604 Military Hospital of Chinese PLA,Lanzhou 730030,Gansu Province,China)

机构地区：[1]中国人民解放军九六六○四部队医院,甘肃兰州730030

出　　处：《中外医药研究》2022年第1期12-14,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察小儿川崎病治疗中应用丙种球蛋白辅助阿司匹林治疗的临床效果及安全性。方法:回顾性分析2019年2月-2022年2月中国人民解放军九六六○四部队医院收治的小儿川崎病患儿80例,依据治疗方法分为丙种球蛋白辅助阿司匹林的辅助治疗组,单独使用阿司匹林的单独治疗组,各40例,统计分析两组临床疗效、症状体征改善时间、血清学检查结果、不良反应发生情况、家长满意度。结果:辅助治疗组患儿的总有效率高于单独治疗组,差异有统计学意义(P<0.05)。辅助治疗组患儿的发热消失时间、皮疹消失时间、黏膜充血缓解时间、四肢症状改善时间、淋巴结肿大消退时间短于单独治疗组,差异有统计学意义(P<0.05)。治疗前,两组患儿的血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞计数(WBC)、血小板计数(PLT)、红细胞沉降率(ESR)、肿瘤坏死因子-α(TNF-α)比较,差异无统计学意义(P>0.05);两组患儿治疗后的血清CRP、IL-6、WBC、PLT、ESR及TNF-α水平均低于治疗前,且辅助治疗组患儿以上指标均低于单独治疗组,差异有统计学意义(P<0.05)。辅助治疗组患儿的不良反应总发生率低于单独治疗组,差异有统计学意义(P<0.05)。辅助治疗组患儿家长满意度高于单独治疗组,差异有统计学意义(P<0.05)。结论:在小儿川崎病治疗中,丙种球蛋白辅助阿司匹林治疗的临床效果及安全性较阿司匹林单独治疗好,且提高患儿家属满意度。Objective:To observe the clinical effect and safety of gamma globulin-assisted aspirin therapy in the treatment of children with Kawasaki disease.Methods:A retrospective analysis was performed among 80 children with Kawasaki disease who were admitted to the 96604 Military Hospital of Chinese PLA from February 2019 to February 2022.According to the treatment methods,they were divided into gamma globulin-assisted aspirin treatment group and aspirin alone treatment group,with 40 cases in each group.The clinical efficacy,symptom and sign improvement time,serological test results,occurrence of adverse reactions,and parental satisfaction were statistically analyzed between the two groups.Results:The total effective rate of the children in the adjuvant treatment group was higher than that in the single treatment group,and the difference was statistically significant(P<0.05).The time of fever disappearance,time of rash disappearance,time of mucosal congestion relief,time of limb symptoms improvement,and time of lymphadenectasis regression in the adjuvant treatment group was shorter than that in the single treatment group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum C-reactive protein(CRP),interleukin-6(IL-6),white blood cell count(WBC),platelet count(PLT),erythrocyte sedimentation rate(ESR),tumor necrosis factor-α(TNF-α)between two groups(P>0.05);after treatment,serum CRP,IL-6,WBC,PLT,ESR and TNF-αlevels in the two groups of children were lower than those before treatment,and the above indexes in the adjuvant treatment group were lower than those in the single treatment group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the adjuvant treatment group was lower than that in the single treatment group,and the difference was statistically significant(P<0.05).The parental satisfaction in the adjuvant treatment group was higher than that in the single treatment group,and the differ

关 键 词：小儿川崎病 丙种球蛋白 阿司匹林 不良反应 家长满意度 

分 类 号：R72[医药卫生—儿科]