类风湿关节炎合并间质性肺病中医证候分布特征性研究  

Study of TCM Syndromes Distribution Characteristics in Rheumatoid Arthritis Complicated with Interstitial Lung Disease

作　　者：彭秋伟 姜泉[1] 巩勋[1] 夏聪敏 王建[1] 李克嵩 PENG Qiuwei;JIANG Quan;GONG Xun;XIA Congmin;WANG Jian;LI Kesong(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医基础医学杂志》2022年第7期1110-1113,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点研发计划项目(2018YFC1705200)-类风湿关节炎中医药治疗方案优化及循证评价研究。

摘　　要：目的:基于类风湿关节炎中医数据中心库(china rheumatoid arthritis data center-traditional chinese medicine,CRDC-TCM)分析类风湿关节炎合并间质性肺病(rheumatoid arthritis-interstitial lung disease,RA-ILD)中医证候分布规律。方法:从CRDC-TCM筛选出122例RA-ILD患者,对中医证候分布情况与一般资料、实验室检查、疾病活动度规律及双手X线分期进行分析。结果:RA-ILD患者的性别、年龄、疾病的活动度及双手X线分期在各个中医证候间比较差异无统计学意义(P>0.05),血红蛋白(hemoglobin,HGB)水平在不同证候间比较差异有统计学意义(P<0.01),湿热痹阻证患者HGB水平最低。白细胞(white blood cell,WBC)、血小板(blood platelet,PLT)、血沉(erythrocyte sedimentation rate,ESR)、C-反应蛋白(c-reactive protein,CRP)、类风湿因子(rheumatoid factors,RF)、抗环瓜氨酸肽抗体(cyclic citrullinated peptide,CCP)及视觉模拟评分(visual analogue scale,VAS)在不同证型间差异均无统计学意义(P>0.05)。结论:RA-ILD中医证候以湿热痹阻证为主,且湿热痹阻证RA-ILD患者关节疾病活动度高,骨与关节损伤较重。Objective:To analyze the distribution of TCM syndromes of rheumatoid arthritis with interstitial lung disease(RA-ILD)based on the China Rheumatoid Databese Center-Traditional Chinese Medicine(CRDC-TCM).Methods:122 RA-ILD patients were screened out from CRDC-TCM,and the distribution of TCM syndromes and general information,course of disease,laboratory examination,disease activity regularity,and X-ray stages of both hands were analyzed.Results:The gender,age,course of disease,activity of the disease,and X-ray staging of the hands of RA-ILD patients were not statistically different among the various TCM syndromes(P>0.05).There were significant statistical differences in HGB levels among different syndrome types(P<0.01).The HGB level of damp-heat syndrome patients was the lowest.WBC,PLT,ESR,CRP,RF,CCP and VAS scores were not statistically different among different syndrome types(P>0.05).Conclusion:The TCM syndrome of RA-ILD was mainly damp-heat type,and the RA-ILD patients with damp-heat type had high activity of joint disease and serious bone and joint injury.

关 键 词：类风湿关节炎 间质性肺病 中医证候 湿热痹阻 

分 类 号：R593.22[医药卫生—内科学] R563.13[医药卫生—临床医学]