平目颗粒治疗非活动期甲状腺相关眼病合并高眼压患者的疗效观察  

Clinical Observation of Pingmu Granule in Treatment of Inactive Thyroid-related Ophthalmopathy with High Intraocular Pressure

作　　者：李红艳 郑鹏飞 闵婕 张亚利[1] 王维 张静文 李红[1] LI Hongyan;ZHENG Pengfei;MIN Jie;ZHANG Yali;WANG Wei;ZHANG Jingwen;LI Hong(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;PLA Amy 949 Hospital,XinJiang Altay 836500,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]解放军陆军第九四九医院,新疆阿勒泰836500

出　　处：《中国中医基础医学杂志》2022年第7期1130-1133,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：上海市科学技术委员会“科技创新行动计划”(实验动物研究领域)资助项目(19140904600)-Graves眼病动物模型的研究;上海市科学技术委员会2018年度医学引导类(中西医)科技支撑项目(18401900800)-针药结合治疗非活动期Graves眼病的优化治疗方案研究;上海市中医药事业发展三年行动计划[ZY(2018-2020-CCCX-2002-08)]-基于黑珠属肝眼胞属脾的五轮学说从肝脾论治Graves眼病研究。

摘　　要：目的:探讨平目颗粒治疗非活动期甲状腺相关眼病伴高眼压患者的临床疗效及安全性。方法:将86例非活动期甲状腺相关眼病合并高眼压患者随机分为中药组和对照组各43例,全部受试者均维持西药基础治疗(降眼压药物除外),中药组给予平目颗粒口服,对照组给予平目颗粒模拟剂口服,2组疗程均为12周,观察2组治疗前后突眼度、眼压、眼眶内球后脂肪体积、下直肌厚度及不良反应。结果:治疗12周后,中药组治疗前后突眼度、眼压、球后眶内脂肪体积、下直肌厚度比较差异有统计学意义(P<0.05,P<0.01),对照组治疗前后各项观察指标比较差异均无统计学意义。治疗后中药组突眼度、眼压、球后眶内脂肪体积、下直肌厚度均低于对照组(P<0.05,P<0.01)。中药组临床疗效(73.81%)优于对照组(24.39%),差异有统计学意义(P<0.01),2组患者均未出现严重不良反应。结论:平目颗粒可有效降低非活动期甲状腺相关眼病合并高眼压患者的突眼度、眼压、球后脂肪体积及下直肌厚度,安全性高。Objective:To investigate the clinical efficacy of Pingmu granule in the treatment of non-active thyroid-related eye diseases with high intraocular pressure.Methods:86 patients with non-active thyroid-related ophthalmopathy complicated with intraocular hypertension were randomly divided into two groups,43 cases in each group.All subjects maintained basic western medicine treatment(except for medications that lower the eye pressure).The Chinese medicine group was given oral Pingmu granule,while the control group was given oral Pingmu granule simulation agent.The treatment course of the two groups were 12 weeks.Eye protrusion,intraocular pressure,posterior orbital fat volume,inferior rectus thickness and adverse reactions were observed before and after treatment in both groups.Results:After 12 weeks of treatment,there were statistically significant differences in the degree of eye protrusion and the thickness of inferior rectus,intraocular pressure and fat volume in retrobulbar orbit before and after treatment in the TCM group(P<0.05,P<0.01).There was no statistical significance in the observation indexes of the control group before and after treatment.Compared with the control group,the degree of ocular protrusion,intraocular pressure,the volume of fat in retrobulbar orbit and the thickness of inferior rectus muscle in TCM group were all lower than those in the control group(P<0.05,P<0.01).After treatment,the clinical efficacy of TCM group(73.81%)was better than that of control group(24.39%),and the difference was statistically significant(P<0.01).No severely adverse reactions were found in both groups.Conclusion:Pingmu granule can effectively reduce the ocular protrusion,intraocular pressure,retrobulbar fat volume and the thickness of inferior rectus muscle in non-active thyroid-associated ophthalompathy with high intraocular pressure patients.

关 键 词：平目颗粒 甲状腺相关眼病 高眼压 球后脂肪体积 

分 类 号：R289.5[医药卫生—方剂学]