DNA感受器在鱼类先天免疫中的功能  

Functions of DNA sensors in innate immunity of fish

作　　者：吴初新 徐小文 WU Chuxin;XU Xiaowen(School of Primary School Education,Yuzhang Normal University,Nanchang 330103,China;College of Life Sciences,Nanchang University,Nanchang 330031,China)

机构地区：[1]豫章师范学院小学教育学院,南昌330103 [2]南昌大学生命科学学院,南昌330031

出　　处：《生物学杂志》2022年第4期104-109,共6页Journal of Biology

基　　金：江西省自然科学基金项目(20202BABL205009);江西省教育厅科学技术研究项目(GJJ191210)。

摘　　要：综述鱼类胞内主要的DNA感受器,包括TLR9/TLR21、STING、cGAS、DDX41和PKZ等的结构、DNA识别机制,分析这些DNA感受器在感知病原微生物所释放的DNA后激活的信号通路、诱导产生I型IFN或炎症因子的分子机制。同时,分析鱼类与哺乳类的DNA感受器的不同之处,提出当前鱼类DNA感受器研究中的不足,为后续深入研究提供参考。This paper reviewed the structures and DNA recognition mechanisms of the main DNA sensors in fish,including TLR9/TLR21,STING,cGAS,DDX41 and PKZ.These DNA sensors could detect the DNA of pathogenic microorganisms,and finally induced the expression of type I IFN and inflammatory factors through a series of signal transduction.In addition,this review analyzed the differences of DNA sensors between fish and mammals,and discussed the deficiencies in the current research of fish DNA sensors.It provided theoretical guidance for further study of fish DNA sensors.

关 键 词：鱼类 DNA感受器 信号通路 先天免疫 

分 类 号：Q51[生物学—生物化学] Q71