血浆分离在肾移植围手术期的应用  

Application of plasmapheresis in perioperative period of kidney transplantation

作　　者：印苏培 张克勤 YIN Supei;ZHANG Keqin(Urinary Nephropathy Center,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400072,P.R.China)

机构地区：[1]重庆医科大学附属第二医院泌尿肾病中心,重庆400072

出　　处：《华西医学》2022年第7期984-988,共5页West China Medical Journal

基　　金：国家自然科学基金(81670684)。

摘　　要：肾移植是治疗终末期肾病的理想方法。针对供者人类白细胞抗原和血型抗原的循环同种异体抗体会损伤同种异体移植,缩短同种异体移植存活时间,并限制肾移植的进行。此外,供者特异性抗体的存在与抗体介导的排斥反应发生率增加和移植后移植物存活率降低有关。血浆分离是一种旨在去除血浆蛋白的体外治疗,已被发现可最大限度地减少肾移植围手术期致敏的影响,血浆分离使得能够跨越ABO血型不相容的障碍进行移植。此外,其也是治疗抗体介导的排斥反应的重要方法。因此,研究血浆分离在肾移植围手术期的应用有望增加移植的机会,并改善移植后的结果,该文介绍了血浆分离在肾移植围手术期的应用。Kidney transplantation is an ideal treatment for patients with end-stage renal disease.Circulating alloantibodies against donor human leukocyte antigens and blood group antigens can impair allografts,shorten allograft survival,and limit access to kidney transplantation.Furthermore,the presence of donor specific antibodies is associated with increased incidence of antibody-mediated rejection and decreased graft survival following transplantation.Plasmapheresis,an extracorporeal therapy directed at removing plasma proteins that has been found to minimize the effects of perioperative sensitization in kidney transplantation.Plasmapheresis enables transplantation across the barrier of ABO blood group incompatibility.In addition,it is also an important approach for the treatment of antibody-mediated rejection.Therefore,studying the application of plasmapheresis in perioperative period of kidney transplantation is expected to increase the chance of transplantation and improve the outcomes following transplantation.This article introduces the application of plasmapheresis in the perioperative period of kidney transplantation.

关 键 词：终末期肾病 肾移植 血浆分离 血浆置换 

分 类 号：R699.2[医药卫生—泌尿科学]