肾小管细胞衰老在急性肾损伤中的研究进展  

Research progress on renal tubular cell senescence in acute kidney injury

作　　者：陈佳 何娅妮 CHEN Jia;HE Yani(Department of Nephrology,Daping Hospital(Army Medical Center),Army Medical University,Chongqing 400038,P.R.China)

机构地区：[1]陆军军医大学大坪医院(陆军特色医学中心)肾内科,重庆400038

出　　处：《华西医学》2022年第7期1076-1080,共5页West China Medical Journal

基　　金：重庆市技术创新与应用发展专项重点项目(cstc2019jscxgksbX0024);陆军军医大学青年培育项目(2019XQN15)。

摘　　要：细胞衰老是一种细胞周期不可逆停滞状态,同时分泌炎症因子、趋化因子等衰老相关分泌表型(senescence-associated secretory phenotype,SASP),在肾脏疾病、代谢性疾病等进展中发挥重要作用。肾小管细胞衰老是急性肾损伤(acute kidney injury,AKI)进展中关键的细胞生物学事件,不仅阻抑AKI再生修复,还可释放SASP促进AKI慢性化进展。抑制肾小管细胞衰老、靶向清除衰老肾小管细胞或是促进衰老细胞凋亡等方法可改善AKI预后,具有广阔的应用前景。Cell senescence is a state of irreversible cell cycle arrest and simultaneously secretes inflammatory factors,chemokines and other senescence-associated secretory phenotype(SASP),which plays an important role in the progression of kidney diseases,metabolic diseases and other diseases.Renal tubular cell(RTC)senescence is a key cellular biological event in the progression of acute kidney injury(AKI).Senescent RTCs not only inhibit the regeneration and repair of AKI,but also release SASP to promote the progression of AKI.Inhibition of RTC senescence,targeted removal of senescent RTCs or promotion of senescent RTCs apoptosis could improve the prognosis of AKI,indicating that these methods have broad application prospects.

关 键 词：肾小管细胞 细胞衰老 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]