间充质干细胞来源的外泌体在缺血再灌注肾损伤中的作用和机制研究进展  

Role and mechanism of mesenchymal stem cell-derived exosomes on renal ischemiareperfusion injury

作　　者：刘艺 张鹏 孙世仁 柏明 LIU Yi;ZHANG Peng;SUN Shiren;BAI Ming(Xi’an Medical University,Xi’an,Shaanxi 710021,P.R.China;Department of Nephrology,Xijing Hospital,Air Force Medical University,Xi’an,Shaanxi 710032,P.R.China)

机构地区：[1]西安医学院,西安710021 [2]空军军医大学西京医院肾脏内科,西安710032

出　　处：《华西医学》2022年第7期1081-1087,共7页West China Medical Journal

基　　金：国家自然科学基金(82070699)。

摘　　要：急性肾损伤(acute kidney injury,AKI)表现为肾功能突然、快速下降,在住院患者中发病率高、病死率高。AKI可由多种病因引起,缺血再灌注损伤(ischemia-reperfusion injury,IRI)是AKI的最常见病因之一。越来越多的研究发现间充质干细胞(mesenchymal stem cell,MSC)来源的外泌体可以通过调节免疫反应、抗氧化应激、对抗细胞凋亡、促进组织再生等机制缓解IRI-AKI,能在一定程度上避免直接应用MSC的限制。该文就MSC来源的外泌体治疗缺血再灌注肾损伤的作用和机制作一综述,为该方向的科研工作者提供参考。Acute kidney injury(AKI)is characterized by a sudden and rapid decline of renal function and associated with high morbidity and mortality.AKI can be caused by various factors,and ischemia-reperfusion injury(IRI)is one of the most common causes of AKI.An increasing number of studies found out that exosomes of mesenchymal stem cells(MSCs)could alleviate IRI-AKI by the adjustment of the immune response,the suppression of oxidative stress,the reduction of cell apoptosis,and the promotion of tissue regeneration.This article summarizes the effect and mechanism of MSC-derived exosomes in the treatment of renal ischemia-reperfusion injury,in order to provide useful information for the researches on this field.

关 键 词：急性肾损伤 缺血再灌注损伤 间充质干细胞 外泌体 

分 类 号：R692[医药卫生—泌尿科学]