海洋源性胶原蛋白用做组织工程材料的研究进展  

Progress in the Research of Marine Collagen in Biomaterials for Tissue Engineering

作　　者：樊廷俊[1] 李琨 赵君[1] Fan Tingjun;Li Kun;Zhao Jun(College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China)

机构地区：[1]中国海洋大学海洋生命学院,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2022年第8期1-9,共9页Periodical of Ocean University of China

基　　金：国家重点研究发展计划项目(2018YFC1106001)资助。

摘　　要：胶原蛋白因具有高生物相容性、可降解性、易得性及低免疫原性等,现已作为理想的生物材料被广泛应用于组织工程器官/组织的体外构建。目前使用的胶原蛋白主要来源于陆生哺乳动物,但该来源存在宗教限制及人畜共患疾病传染风险。海洋源性胶原蛋白(Marine collagen,mCOL)不但在氨基酸组成和生物相容性方面与陆生动物胶原蛋白高度相似,更胜在来源广泛、易于提取、不存在病原微生物污染且具有稳定的化学和物理特性等。然而目前对于其作为生物材料在组织工程中的应用尚没有系统的论述。本文对mCOL的来源、特性及提取工艺进行了概述,并对其目前作为生物材料在组织工程中的应用进展进行了重点阐述,同时展望了mCOL作为理想器官和组织再生材料来源的可能性,为开发利用mCOL应用于组织工程器官和组织再生提供建议与参考。For the high biocompatibility,biodegradability,easy extractability and low immunogenicity,collagen has been widely used as an ideal biomaterial for the construction of the tissue engineering organ and tissue in vitro.At present,collagen mainly comes from mammals,but the religious restrictions and the risk of zoonotic diseases are existed.Marine collagen(mCOL)is not only highly similar to the terrestrial collagen in amino acid composition and biocompatibility,but also has better chemical and physical properties,wide source,easy extraction,no pathogenic microorganism pollution and so on.Howe-ver,there is no systematic discussion on its application in biomaterials for tissue engineering.In this review,the source,characteristics and extraction process of mCOL were systematically summarized,and the application progress of mCOL in biomaterials for tissue engineering was emphatically described.Meanwhile,the possibility of mCOL as an ideal source of organ and tissue regeneration materials was prospected,which provided suggestions and reference for the development and utilization of mCOL in tissue engineering organ and tissue regeneration.

关 键 词：胶原蛋白 海洋源性胶原蛋白 生物材料 组织工程器官和组织 再生 

分 类 号：Q811.9[生物学—生物工程]