促甲状腺激素表达的相关影响因素及对某高海拔地区人群甲亢的预判价值研究  

Related factors of thyroid stimulating hormone expression and its predictive value for hyperthyroidism in people living in a high altitude area

作　　者：杨敏[1] 吴洋 叶黄锋 杨金花 许颖[1] YANG Min;WU Yang;YE Huangfeng;YANG Jinhua;XU Ying(Department of Clinical Laboratory,the First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China;Department of Clinical Laboratory,People′s Hospital of Maerkang,Maerkang,Sichuan 624000)

机构地区：[1]成都医学院第一附属医院检验科,四川成都610500 [2]马尔康市人民医院检验科,四川马尔康624000

出　　处：《徐州医科大学学报》2022年第7期500-502,共3页Journal of Xuzhou Medical University

基　　金：四川省教育厅高校科研创新团队(17TD0012);成都医学院科研创新团队(CYTD15-03)。

摘　　要：目的通过对某海拔2600米城市1915名机关事业单位人群健康体检血清促甲状腺激素(TSH)检查结果进行回顾性分析,探讨高海拔地区影响血清TSH异常表达的因素。方法2017年9月对某海拔2600米城市1915名机关事业单位人群予甲状腺功能检查,体检空腹血清TSH、甲状腺素(TT_(4))、三碘甲腺原氨酸(TT_(3))、游离甲状腺素(FT_(4))、游离三碘甲腺原氨酸(FT_(3))指标,分析检测结果,并对影响血清TSH异常表达因素进行探讨;另于同期选取正常海拔水平1900名机关事业单位人群予以甲状腺功能检查,分析血清TSH异常表达与海拔水平的关系。结果高海拔地区1915名研究对象中TSH异常者321例(16.76%),正常海拔地区1900名研究对象中TSH异常者125例(6.58%),2组相比差异有统计学意义(P<0.05)。高海拔地区321例血清TSH异常者TT_(4)、TT_(3)、FT_(4)、FT_(3)水平与正常者相比差异无统计学意义(P>0.05),且TSH异常率随年龄增长而升高,女性各年龄段TSH异常者比率均高于男性(P<0.05)。结论高海拔地区人群血清TSH异常率较高,且女性高于男性,因此对高海拔地区妊娠期妇女应加强甲状腺功能监测。Objective To analyze serum thyroid stimulating hormone(TSH)in 1915 people in government departments and institutions living at an altitude of 2600 meters,and explore the factors affecting the abnormal expression of serum TSH.Methods In September 2017,thyroid function tests were performed on 1915 people in government departments and institutions at an altitude of 2600 meters above sea level.Their fasting blood samples were collected to measure TSH,thyroxine(TT_(4)),triiodothyronine(TT_(3)),free thyroxine(FT_(4)),and free triiodothyroglastin(FT_(3)),and the factors affecting the abnormal expression of TSH were discussed.Meanwhile,thyroid function tests were performed on another 1900 people in in government departments and institutions at a normal altitude area to analyze the relationship between abnormal expression of TSH and altitude.Results There were 321 subjects with abnormal TSH in the high altitude area(16.76%)and 125 subjects with abnormal TSH in the normal altitude area(6.58%),with statistical difference(P<0.05).There were no statistical difference in TT_(4),TT_(3),FT_(4) and FT_(3) between subjects with normal and abnormal TSH in the high altitude area(P>0.05).With the increase of ages,the percentage of female subjects with abnormal TSH in each age range was higher than that of male subjects(P<0.05).Conclusions The percentage of abnormal thyrotropin is high in the population living in the high altitude area,especially for women.It is necessary to monitor the thyroid function for women in pregnancy.

关 键 词：高海拔 血清促甲状腺激素 甲状腺功能减退 甲状腺疾病 

分 类 号：R446.11[医药卫生—诊断学]