来曲唑在多囊卵巢综合征反复种植失败患者冻融囊胚移植周期中的应用  

Application of letrozole in the frozen blastocyst transfer cycles for womenwith polycystic ovary syndrome and recurrent implantation failure

作　　者：熊永崂[1] 蔡桂丰[1] 杨嫦玉[1] 周雯雯[1] 梁晓燕[2] Xiong Yonglao;Cai Guifeng;Yang Changyu;Zhou Wenwen;Liang Xiaoyan(Reproductive Medical Center,Zhuhai Maternal and Child Health Hospital,Zhuhai Guangdong 519000;Reproductive Center,The Sixth Affiliated Hospital of Sun Yat-Sen University,Guangzhou Guangdong 510000,P.R.China)

机构地区：[1]珠海市妇幼保健院生殖医学中心,广东珠海519000 [2]中山大学附属第六医院生殖中心,广东广州510000

出　　处：《中国计划生育和妇产科》2022年第7期42-44,共3页Chinese Journal of Family Planning & Gynecotokology

基　　金：珠海市科技计划项目(项目编号:ZH2202200064HJL)。

摘　　要：目的研究来曲唑刺激周期在多囊卵巢综合征反复种植失败患者再次行冻融囊胚移植中的疗效。方法收集2018年1月至2019年12月在珠海市妇幼保健院生殖中心反复种植失败后再次行冻胚移植的多囊卵巢综合征132例患者的临床资料,研究组为来曲唑刺激周期共46例,对照组为人工激素替代周期共86例。比较两组患者的临床妊娠率、活产率及流产率等妊娠结局。结果两组患者的一般资料比较,差异均无统计学意义(P>0.05)。研究组子宫内膜厚度(9.61±1.56)mm、临床妊娠率(61.0%)、囊胚种植率(58.8%)、活产率(61.0%)均显著高于对照组[(8.78±1.86)mm,40.7%,39.2%,37.2%],差异有统计学意义(P<0.05)。两组的生化妊娠率和流产率比较,差异无统计学意义(P>0.05)。结论来曲唑作为多囊卵巢综合征反复种植失败患者再次行冻胚移植周期中的内膜准备方案可明显改善临床结局。Objective To investigate the efficacy of letrozole in the frozen blastocyst transfer cycles for women with polycystic ovary syndrome and recurrent implantation failure.Methods The clinical data of 132 patients of frozen blastocyst transfer cycles for women with polycystic ovary syndrome and recurrent implantation failure in Zhuhai Maternal and Child Health Hospital from January 2018 to December 2019 were retrospectively collected.The study group received letrozole stimulation cycle(46 cases),and the control group received hormone replacement cycle(86 cases).The clinical pregnancy rate,live birth rate and abortion rate were compared between the two groups.Results There was no significant difference in general data between the two groups(P>0.05).The endometrial thickness(9.61±1.56)mm,clinical pregnancy rate(61.0%),blastocyst implantation rate(58.8%)and live birth rate(61.0%)in the study group were significantly higher than those in the control group[(8.78±1.86)mm,40.7%,39.2%,37.2%],the differences were statistically significant(P<0.05).There was no significant difference in biochemical pregnancy rate and abortion rate between the two groups(P>0.05).Conclusion Letrozole as an endometrial preparation for women with polycystic ovary syndrome and recurrent implantation failure in the frozen blastocyst transplantation cycles can significantly improve clinical outcomes.

关 键 词：来曲唑 多囊卵巢综合征 冻融囊胚移植 反复种植失败 

分 类 号：R711.6[医药卫生—妇产科学] R711.75[医药卫生—临床医学]