甲状腺自身抗体阳性对甲状腺功能正常女性冻融胚胎移植妊娠结局的影响  

Effect of antithyroid antibody positive on pregnancy outcomes of frozenthawedembryo transfer in women with normal thyroid function

作　　者：梁慧枝 王治鸿[2] 杨园 段霞 康宜凡 杨盼 Liang Huizhi;Wang Zhihong;Yang Yuan;Duan Xia;Kang Yifan;Yang Pan(Shanxi Medical University,Taiyuan Shanxi 030001,P.R.China;Reproductive Medicine Center,First Hospital of Shanxi Medical University,Taiyuan Shanxi 030001,P.R.China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一医院生殖医学中心

出　　处：《中国计划生育和妇产科》2022年第7期50-53,共4页Chinese Journal of Family Planning & Gynecotokology

基　　金：山西省重点研发计划(项目编号:201903D321163)。

摘　　要：目的探讨甲状腺自身抗体(antithyroid antibody,ATA)阳性对甲状腺功能正常女性行冻融胚胎移植(frozen-thawed embryo transfer,FET)妊娠结局的影响。方法回顾性分析2019年1月至2020年1月在山西医科大学第一医院生殖中心首次接受FET治疗且甲状腺功能正常的437例患者资料,其中ATA阳性者106例(ATA+组),ATA阴性者331例(ATA-组)。比较两组患者一般资料、临床指标的差异,分析ATA对FET妊娠结局的影响。结果两组一般资料比较(移植日内膜厚度、移植日激素水平、移植的优质胚胎个数、胚胎冻存时间等)差异无统计学意义(P>0.05),临床妊娠率、生化妊娠率、流产率、活产率、早产率、低出生体重率(59.2%,4.9%,14.8%,85.2%,25.0%,30.8%vs 49.8%,7.7%,19.3%,80.7%,23.1%,21.5%)比较差异无统计学意义(P>0.05)。结论ATA对甲状腺功能正常患者FET妊娠结局没有显著影响。Objective To investigate the effect of antithyroid antibody(ATA)positive on pregnancy outcomes in the patients with normal thyroid function undergoing frozen-thawed embryo transfer(FET).Methods The data of 437 patients with normal thyroid function who received FET treatment for the first time in the reproductive center of the First Hospital of Shanxi Medical University from January 2019 to January 2020 were retrospectively analyzed,of which 106 were ATA positive(ATA+group)and 331 were ATA negative(ATA-group).The differences in general data and clinical indicators between the two groups were compared,and the effect of ATA on the pregnancy outcome of FET was analyzed.Results There was no statistical difference between the two groups in general data(endometrial thickness on the day of transplantation,hormone levels on the day of transplantation,the number of high-quality embryos transferred,and embryo cryopreservation time,etc.)(P>0.05).The clinical pregnancy rate,biochemical pregnancy rate,and abortion rate,live birth rate,preterm birth rate,low birth weight rate between the two groups had no statistical difference(59.2%,4.9%,14.8%,85.2%,25.0%,30.8%vs 49.8%,7.7%,19.3%,80.7%,23.1%,21.5%)(P>0.05).Conclusion ATA had no significant effect on FET pregnancy outcomes in euthyroid patients.

关 键 词：冻融胚胎移植 甲状腺自身性免疫 甲状腺功能正常 甲状腺自身抗体 妊娠结局 

分 类 号：R71[医药卫生—妇产科学]