唐氏筛查指标与妊娠期高血压疾病的相关性研究  

Correlation research between Down's screening indicators and hypertensivedisorders of pergnancy

作　　者：钟文 何雪莲[1] 罗小兰 王艳 王旋 唐丽娟[2] 梁羽[2] 刘谢芹 敖丽 高岩[1] Zhong Wen;He Xuelian;Luo Xiaolan;Wang Yan;Wang Xuan;Tang Lijuan;Liang Yu;Liu Xieqin;Ao li;Gao Yan(Department of Obstetrics,Sichuan Maternal and Child Health Hospital,Chengdu Sichuan 610041;Clinical Medical College of Chengdu Medical College,Chengdu Sichuan 610500,P.R.China)

机构地区：[1]四川省妇幼保健院产科,四川成都610041 [2]成都医学院临床医学院,四川成都610500

出　　处：《中国计划生育和妇产科》2022年第7期98-102,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探索唐氏筛查指标与妊娠期高血压疾病(hypertensive disorders of pergnancy,HDP)的相关性。方法回顾性分析2017年6月至2019年6月在四川省妇幼保健院建卡、产检、分娩且孕期于该院进行过唐氏综合征筛查的所有自然怀孕单胎妊娠孕妇。根据纳入及排除标准筛选出207例HDP患者为HDP组,4556例正常孕妇为对照组。分析两组一般临床特征及特异性血清学指标的差异性,Logistic回归模型用于探索HDP发病的相关因素。结果单因素分析游离β-人绒毛膜促性腺激素(Freeβ-human chorionic gonadotropin,Freeβ-hCG)、妊娠相关血浆蛋白A(pregnancy associated plasma protein-A,PAPP-A)与HDP呈显著负相关(P<0.05),甲胎蛋白(alpha fetoprotein,AFP)、抑制素(Inhibin A)与HDP差异无统计学意义(P>0.05);Logistic回归模型进一步验证了Freeβ-hCG、PAPP-A与HDP的发生存在显著相关性(OR=0.778、0.640,P=0.032、0.003),AFP、Inhibin A与HDP差异无统计学意义(P>0.05)。Freeβ-hCG MOM值平均每增加1个单位,患者发生HDP的风险平均降低22.2%;PAPP-A MOM值平均每增加1个单位,患者发生HDP的风险平均降低36.0%。结论Freeβ-hCG、PAPP-A与HDP的发生存在显著相关性,Freeβ-hCG、PAPP-A可作为HDP的预测指标预测HDP的发生。Objective To explore the correlation between Down's screening indicators and hypertensive disorders of pergnancy(HDP).Methods A retrospective analysis of all pregnant singleton pregnant women with natural pregnancies who were in Sichuan Maternal and Child Health Hospital from June 2017 to June 2019,had card establishment,obstetric check-ups,delivery,and had undergone Down's syndrome screening in the hospital during pregnancy.According to the inclusion and exclusion criteria,207 patients with HDP were selected as HDP group and 4556 normal pregnant women as control group.The differences of general clinical characteristics and specific serological indexes between the two groups were analyzed,and the Logistic regression model was used to explore the factors related to the onset of HDP.Results In univariate analysis,Freeβ-human chorionic gonadotropin(Freeβ-hCG),pregnancy associated plasma protein-A(PAPP-A)were significantly negatively correlated with HDP(P<0.05),and the differences between alpha fetoprotein(AFP),Inhibin A and HDP was not statistically significant(P>0.05);Logistic regression model further verified that there was a significant correlation between Freeβ-hCG,PAPP-A and the occurrence of HDP(OR=0.778,0.640,P=0.032,0.003),and there was no difference between AFP,Inhibin A and HDP(P>0.05).An average increase in Freeβ-hCG MOM value by one unit reduces the patient’s risk of HDP by an average of 22.2%;an average increase in PAPP-A MOM value by one unit reduces the patient’s risk of HDP by an average of 36.0%.Conclusion Freeβ-hCG and PAPP-A were significantly correlated with the occurrence of HDP,and Freeβ-hCG,PAPP-A can be used as predictors of HDP to predict the occurrence of HDP.

关 键 词：妊娠期高血压疾病 唐氏筛查 相关性分析 

分 类 号：R714.25[医药卫生—妇产科学]