结核病疫苗及其在动物应用中的研究进展  

Research Progress of Tuberculosis Vaccine and Its Animal Application

作　　者：姜秀云[1] 方诗文 姚宇 吴水银 JIANG Xiuyun;FANG Shiwen;YAO Yu;WU Shuiyin(College of Life Science,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]吉林农业大学生命科学学院,长春130118

出　　处：《经济动物学报》2022年第1期1-10,共10页Journal of Economic Animal

基　　金：国家自然科学基金(31572555);吉林省科技发展计划项目(20170101025JC)。

摘　　要：结核病作为人兽共患传染病,近年全球每年感染人数近千万,死亡140余万,同时,给动物养殖业造成损失达30亿美元。预防结核病最有效的方法是接种疫苗,但传统的卡介苗人用效果不理想,动物应用又存在很大局限性,因此,亟待研制更有效、更适宜的结核病疫苗,以应对结核病的威胁。文中对近年来结核病新型疫苗及其在动物应用中的研究进行了综述。Tuberculosis is a zoonotic infectious disease. In recent years, the number of people infected with tuberculosis is nearly 10 million, more than 1.4 million people die, and the loss of animal breeding industry up to 3 billion US dollars. Vaccination is the most effective way to prevent tuberculosis, but the effect of traditional BCG vaccine for human use is not ideal, and animal application has great limitations. Therefore, it is urgent to develop a more effective and suitable tuberculosis vaccine to deal with the threat tuberculosis. This article reviews the research progress of new tuberculosis vaccines and their application animals in recent years.

关 键 词：结核病 重组卡介苗 DNA疫苗 亚单位疫苗 活载体疫苗 

分 类 号：S855.2[农业科学—临床兽医学]