微流控技术在机械工程-生命科学交叉领域的应用  

Applications of Microfluidic Technology in Cross-domain of Mechanical Engineering and Life Science

作　　者：满佳[1,2] 华泽升 夏荷 李建勇[1,2] 李方义[1,2] 李剑峰[1,2] MAN Jia;HUA Zesheng;XIA He;LI Jianyong;LI Fangyi;LI Jianfeng(Key Laboratory of High Efficiency and Clean Mechanical Manufacture,Ministry of Education,School of Mechanical Engineering,Shandong University,Jinan,250061;National Demonstration Center for Experimental Engineering Education,Shandong University,Jinan,250061)

机构地区：[1]山东大学机械工程学院,高效洁净机械制造教育部重点实验室,济南250061 [2]山东大学机械工程国家级实验教学示范中心,济南250061

出　　处：《中国机械工程》2022年第15期1857-1868,共12页China Mechanical Engineering

基　　金：国家自然科学基金(51905312,52075304);中国博士后科学基金(2020M6720)。

摘　　要：以微流控技术为研究对象,介绍了微流控芯片的制备材料及工艺,阐述了微流控技术在生命科学交叉领域的应用,主要从生物检测、体外结构仿生制造及可控释放的药物载体制备三方面展开介绍;从芯片结构设计及制备、功能模块集成、过程调控等方面入手,探讨了所涉及的关键技术;展望了微流控技术在机械工程-生命科学交叉领域的应用前景。Taking microfluidic technology as the research object,the preparation materials and technology of microfluidic chips were introduced,and the applications of microfluidic chip technology in the cross fields of life science were emphasized.It was mainly introduced from three aspects:biological detection,bionic fabrication of in vitro structure and preparation of controllable drug carriers,and the key technologies involved were discussed from the aspects of chip structure design and preparation,functional module integration,process regulation and so on.The application prospect of microfluidic technology in the fields of cross-domain between mechanical engineering and life science was prospected.

关 键 词：机械工程 生命科学 微流控 生物检测 仿生 药物载体制备 

分 类 号：TB17[生物学—生物工程]