基于光纤测温系统的1064 nm光纤激光辐照脂肪组织的温度监控试验研究  

Experimental Study on Temperature Monitoring of Adipose Tissue Irradiated by 1 064 nm Fiber Laser Based on Optical Fiber Temperature Measuring System

作　　者：王浩[1,2,3] 屈惠明 王心醉[2,3] 杜大勇[4] 王方军 Wang Hao;Qu Huiming;Wang Xinzui;Du Dayong;Wang Fangjun(Schoolof Electronic and Optical Engineering,Nanjing University ofScience&Technology Nanjing,Jiangsu 210094,China;Jihua Laboratory,Foshan,Guangdong 528200,China;Suzhou Institute of Biological and Medical Engineering,Chinese Academy of Sciences,Suzhou Jiangsu 215163,China;Beijing Huaxiaguanggu Photoelectric Technology Co.,Lid.,Beijing 100088.China;Center of Commercialization for Aduanced Sensors,SinoGerman College of Intelligent Manufacturing,Shenzhen Technology University Shenzhen,Guangdong 518118,China)

机构地区：[1]南京理工大学电子工程与光电技术学院,江苏南京210094 [2]季华实验室,广东佛山528200 [3]中国科学院苏州生物医学工程研究所,江苏苏州215163 [4]北京华夏光谷光电技术有限公司,北京100088 [5]深圳技术大学中德智能制造学院,先进传感器产业化中心,广东深圳518118

出　　处：《应用激光》2022年第4期186-193,共8页Applied Laser

基　　金：国家重点研发计划(2019YFC0121300);广东省省级重大科研项目(2018KZDXM077);季华实验室项目(X190341TD190);深圳技术大学新引进高端人才财政补助科研启动项目(1814309011180001)。

摘　　要：激光融脂(laser lipolysis)技术处于较为初步的阶段,目前研究缺少适用人体的参数信息。在激光融脂过程中,温度作为一个重要的量却难以进行实时监控。结合多路光栅光纤测温系统,通过一系列的试验,研究1 064 nm Nd:YAG连续激光在离体猪脂肪样本中的穿透能力、温度分布,以及功率密度、辐照时间等对脂肪温升的影响,设计并验证持续融脂的试验方案。研究结果表明,连续1 064 nm Nd:YAG激光的脂肪透射能力在2 mm以内;其光热效应产生的热量分布也集中在径向、轴向5 mm以内的组织中。另外,温度分布与照射脂肪激光的功率密度、照射时间有着密切的联系;照射温度达到35℃后,一定时间内将温度控制在安全范围内的参数为:功率密度27.08 W/cm,照射时间16 s,自然冷却9 s;功率密度40.62 W/cm,照射时间9 s,自然冷却9 s。Laser lipolysis technology is in a relatively preliminary stage, and the current research lacks the parameter information applicable to human body. In the process of laser lipid dissolving, temperature, as an important quantity, is difficult to be monitored in real time. In this paper, the effects of 1 064 nm Nd: YAG continuous laser on the temperature rise of pig fat were studied through a series of experiments in combination with the multi-channel grating optical fiber temperature measurement system. The experimental scheme of continuous fat dissolution was designed and verified. Results show that the transmissive power of 1 064 nm Nd: YAG laser in fat is less than 2 mm. The heat distribution generated by the photothermal effect is also concentrated in the radial and axial tissues within 5 mm. In addition, the temperature distribution is closely related to the power density and irradiation time of the fat laser. After the irradiation temperature reaches 35 ℃, the parameters that keep the temperature within the safe range within a certain period of time are: power density 27.08 W/cm~2, irradiation time 16 s, natural cooling 9 s;power density 40.62 W/cm~2, irradiation time 9 s, natural cooling 9 s.

关 键 词：激光安全 连续激光 离体脂肪 温度监控 

分 类 号：Q631[生物学—生物物理学]