糖足1号治疗湿热毒邪伤阴之糖尿病足的临床疗效  

Clinical Efficacy of Tangzu No.1 in Treating Diabetic Foot Caused by Damp-heat Poisoning Yin

作　　者：甘宇[1] 陈盛业[1] GAN Yu;CHEN Sheng-Ye(Department of Endocrinology,Seventh People's Hospital of Shenyang City,Shenyang 110000,China)

机构地区：[1]沈阳市第七人民医院内分泌科,沈阳110000

出　　处：《中国药物经济学》2022年第6期74-77,82,共5页China Journal of Pharmaceutical Economics

基　　金：沈阳市科学计划项目(19-112-4-033)。

摘　　要：目的 探讨糖足1号治疗湿热毒邪伤阴之糖尿病足(DF)的临床疗效。方法 选取2020年1—6月于沈阳市第七人民医院就诊的DF患者100例作为研究对象,将其按就诊病例号随机分为对照组与观察组,各50例。两组患者入院后均对基础疾病进行相应治疗,对照组在基础治疗上对溃疡感染创面进行消毒清创及抗感染处理,之后在创面表面外涂康复新液,最后用无菌纱布覆盖并包扎。观察组治疗措施为将对照组的康复新液外涂替换为糖足1号中药复方外用,中药外敷20min后,清水冲洗后包扎。两组患者均清创并更换药物1次/d,连续治疗1个月,并进行3个月随访。疗程结束后,对两组患者治疗前后的中医证候评分、创面愈合情况、视觉模拟评分法(VAS)评分、腓总神经传导速度、单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)、治疗有效率及不良反应情况进行对比分析。结果 治疗后,对照组及观察组中医临床症状评分、MCP-1水平、VAS评分均有不同程度降低,IGF-1、VEGF水平均较治疗前有所升高,溃疡面积均有所缩小,神经传导速度均有所增加,观察组各指标改善程度更显著,差异有统计学意义(P<0.05)。观察组治疗有效率为98.00%,明显高于对照组的92.00%,差异有统计学意义(P<0.05)。治疗期间及随访3个月,两组患者均未出现肝功能异常、胃肠道不适、过敏等不良反应。结论 应用糖足1号对DF患者治疗具有确切疗效,其可以抑制体内炎症反应,促进血管组织修复,从而使患者的临床症状减轻,促进溃疡面的愈合,加快神经功能恢复,最终达到治疗的目的。同时糖足1号短期内的治疗安全性尚可。Objective To explore the clinical efficacy of Tangzu No.1 in treating diabetic foot caused by damp-heat poisoning yin.Methods 100 patients with diabetic foot who were treated in Shenyang No.7 People’s Hospital from January 2020 to June 2020 were selected.They were randomly divided into the control group(50 cases) and the observation group(50 cases).After admission,the patients in both groups were given corresponding treatment for basic diseases,while the patients in the control group were treated with disinfection,debridement and anti-infection treatment for ulcer infected wounds,then a layer of rehabilitation liquid was coated on the surface of the wounds,and finally covered and bandaged with sterile gauze.In the observation group,the external application of Kangfuxin solution in the control group was replaced by external application of Tangzu No.1 traditional Chinese medicine compound.After external application of traditional Chinese medicine for 20 minutes,it was washed with clear water and then bandaged.Patients in both groups were debrided and replaced once a day,treated continuously for one month,and followed up for three months.After the course of treatment,the TCM syndrome score,wound healing,VAS pain score,common peroneal nerve conduction velocity,monocyte chemoattractant protein-1(MCP-1) in serum,insulin-like growth factor-1(IGF-1) in serum,vascular endothelial growth factor(VEGF) levels,effective rate of treatment and adverse reactions were compared and analyzed between the two groups before and after treatment.Results After the treatment in this study,the TCM clinical symptom score,MCP-1 level and VAS score in the control group and the observation group all decreased to varying degrees,IGF-1 and VEGF levels all increased,ulcer area all decreased,nerve conduction velocity all increased,and the improvement degree of each index in the observation group was more significant,the difference was statistically significant(P<0.05).was more significant,with statistical significance(P<0.05).After treatment,the

关 键 词：糖尿病足 湿热毒邪 中医外治法 

分 类 号：R587.2[医药卫生—内分泌] R289.6[医药卫生—内科学]