乌司他丁联合磷酸奥司他韦治疗重症甲型H1N1流感肺炎的效果  

Effect of Ulinastatin Combined with Oseltamivir Phosphate in the Treatment of Severe Influenza A H1N1 Pneumonia

作　　者：陈冠逹 尹姣 CHEN Guan-Da;YIN Jiao(Department of Emergency,The First People's Hospital of Shenyang City,Shenyang 110041,China)

机构地区：[1]沈阳市第一人民医院急诊科,沈阳110041

出　　处：《中国药物经济学》2022年第6期90-92,117,共4页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨乌司他丁联合磷酸奥司他韦治疗重症甲型H1N1流感肺炎的效果。方法 选取2019年8月至2021年1月沈阳市第一人民医院收治的86例重症甲型H1N1流感肺炎患者作为研究对象,按随机数字表法分为对照组和观察组,各43例。对照组予以单纯磷酸奥司他韦治疗,观察组在磷酸奥司他韦基础上联合乌司他丁治疗,比较两组的治疗效果。结果 观察组治疗有效率为95.35%,高于对照组的76.74%,差异有统计学意义(P<0.05);观察组患者治疗后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05)。结论 重症甲型H1N1流感肺炎实施乌司他丁联合磷酸奥司他韦治疗效果显著,能够有效改善患者机体炎症介质水平,调节T淋巴细胞亚群水平,提高机体免疫能力。Objective To explore thel effect of ulinastatin combined with oseltamivir phosphate for severe influenza A H1N1pneumonia.Methods Eighty-six patients with severe influenza A H1N1 pneumonia admitted to The First People’s Hospital of Shenyang City between August 2019 and January 2021 were selected as observation objects.The patients were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with oseltamivir phosphate only,and the observation group was treated with oseltamivir phosphate combined with ulinastatin.The therapeutic effects of the two groups were compared.Results The effective rate of the observation group was 95.35%,which was higher than 76.74% of the control group,and the difference was statistically significant (P<0.05);The TNF-α,IL-6 and IL-8 of the observation group were lower than the control group after treatment,the difference was statistically significant (P<0.05);After treatment,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+) of the patients in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05).Conclusion The treatment of severe influenza A H1N1 pneumonia with ulinastatin combined with oseltamivir phosphate can effectively improve the level of inflammatory factors in the patient’s body,regulate the level of T lymphatic subgroups,and improve the immunity of the patient’s body.

关 键 词：重症甲型H1N1流感肺炎 乌司他丁 磷酸奥司他韦 T淋巴细胞亚群 炎症介质 

分 类 号：R563.1[医药卫生—呼吸系统] R974[医药卫生—内科学]