基于络病理论探讨难治性Meige综合征病机及治疗  

The pathogenesis and treatment of refractory Meige syndrome based on the theory of collateral disease

作　　者：陈云梦 杨洪军[2] 赵子珺 陈蔚 孟圆 何一鑫 杨保林[3] Chen Yunmeng;Yang Hongjun;Zhao Zijun;Chen Wei;Meng Yuan;He Yixin;Yang Baolin(Beijing University of Chinese Medicine,Beijing 100029,China;Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Department of Neurology,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院医学实验中心,北京100700 [3]北京中医药大学东直门医院脑病科一区,北京100700

出　　处：《国际中医中药杂志》2022年第6期601-605,共5页International Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究计划(973计划)项目(2015CB554406);中国中医科学院基本科研业务自主选题项目(ZZ13-019)。

摘　　要：Meige综合征是神经内科罕见疾病,主要表现为眼部及口面肌痉挛,其发病机制尚未清楚,临床无根治方法,治疗以提高生活质量为主。基于络病理论及其与五脏生理、病理互相影响的关系,认为难治性Meige综合征应属络病,病位在脑,与五脏密切相关,病机为五脏气血失和,虚、痰、瘀滞于络脉致脑髓失养,筋脉失濡。以"通脉和络"为治疗总则,"调整体以愈局部、和五脏以养脑髓"为治疗关键,并自拟通脉和络方治疗。该方以黄芪建中汤佐以益气养血、活血通络方药加减而成,意在通过温养平和之剂健运中焦,达到益五脏气血之源、调人体气机之枢的作用,临床应用获良效。Meige syndrome is one of the rare Diseases of neurology.It is a part of the group of segmental cranial dystonia,which affects more than two cranial muscle groups.Especially,blepharospasm is associated with another cranial dystonia.Currently,the etiology and pathogenesis of this disorder are not well-understood.Based on the theory of collaterals and the relationship between collateral disease and five zang organs,we try to classify the disease into the category of collateral disease,and hold that the mechasnism of disease is not only linked to brain,but also the five zang organs.The disorder of qi and blood leads to the"deficiency of qi and blood","phlegm-damp"and"stagnant blood"in collateral.These pathological changes cause the deficiency of both qi and blood in brain marrow and tendon.We think that"unblocking and regulating the collterals"is the general program.Adjusting the five zang organs to heel the brain is the key point of the treatment.What's more,we create Tongmai Heluo Decoction to regulate qi and blood of the collateral.This decoction is composed of Huangqi Jianzhong Decoction with some herbal medicine for tonifying qi and activating blood.By adjusting the middle energizer,the qi and the qi movement of five zang organs are well regulated.We use this decoction effectively on refractory Meige syndrome.

关 键 词：MEIGE综合征 络病理论 中医病机 通脉和络方 

分 类 号：R277.7[医药卫生—中医学]