基于对氯苯酚合成对羟基苯乙醇研究  

Synthesis of p-Hydroxyphenethyl Alcohol from p-Chlorophenol

作　　者：汪爱春 贺兴宇 WANG Ai-chun;HE Xing-yu(Haili Guixi New Material Technology Co.,Ltd.,Guixi 335400,China;National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry Co.,Ltd.,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China)

机构地区：[1]海利贵溪新材料科技有限公司,江西贵溪335400 [2]湖南化工研究院有限公司国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014

出　　处：《精细化工中间体》2022年第3期20-22,36,共4页Fine Chemical Intermediates

基　　金：湖南省企业科技创新创业团队项目(湖南海利新材料科技创新创业团队)。

摘　　要：以对氯苯酚为原料,与异丁烯反应成醚保护羟基,经格氏反应后,通入环氧乙烷得到对叔丁氧基苯乙醇,再经氢溴酸水解得到对羟基苯乙醇。反应总收率69%(以对氯苯酚计),含量≥98.5%。解决了对羟基苯乙酸乙酯还原法成本高及苯乙醇合成法废水量大的问题,具有工业化应用前景。p-Chlorophenol was used as the raw material,it reacted with isobutylene to form ether bonds to protect the hydroxyl group,and p-tert-butoxyphenylethanol was obtained through reactions of Grignard reaction and reaction of ethylene oxide.p-tert-Butoxyphenylethanol was then hydrolyzed using hydrobromic acid to obtain p-hydroxyphenylethanol.The total yield was 69%(as p-chlorophenol)and the purity was≥98.5%.This method solved the problems of high cost of produced p-hydroxyphenylacetic acid reduction method and large amount of wastewater from p-phenylethanol synthesis method,and has the prospect of industrial application.

关 键 词：对氯苯酚 格氏化反应 酸解 

分 类 号：TQ243.4[化学工程—有机化工]