父体慢性应激对生殖细胞重编程的影响及其机制  

Effect of chronic paternal stress on reproductive cell reprogramming and its mechanism

作　　者：陈铭 肖浩[1] 李庆贤 汪晖[2] 陈廖斌[1] Chen Ming;Xiao Hao;Li Qingxian;Wang Hui;Chen Liaobin(Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Pharmacology,Basic Medical School of Wuhan University,Hubei Provincial Key Laboratory of Developmentally Originated Disease,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院骨科,武汉430071 [2]武汉大学基础医学院药理学系,武汉大学发育源性疾病湖北省重点实验室,武汉430071

出　　处：《中华生殖与避孕杂志》2022年第4期425-430,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(81673490, 81972036)。

摘　　要：父体慢性应激不仅可造成父体本身多脏器、多系统的损伤, 还可将危害传递至子代。而且, 父体慢性应激对子代的危害与生殖细胞重编程有关。当前观点认为, 生殖细胞命运的转变和发育潜能的维持源于表观遗传修饰。因此, 一旦应激因素在特定时期导致父体生殖细胞发生表观遗传修饰改变, 则可引起生殖细胞出现重编程, 进而将危害传递至子代甚至多代。但是, 父体慢性应激导致生殖细胞重编程的发生机制尚未完全阐明。本文综述了父体慢性应激对父体本身及其子代多代的危害, 并结合最新研究进展探讨父体慢性应激影响生殖细胞重编程的发生机制, 以期为父源性疾病提供更多理论依据。Paternal chronic stress can not only cause damage to multiple organs and systems of the paternal itself,but also transmit the harm to the offspring.Moreover,the harm caused by paternal chronic stress to the offspring is related to reprogramming of germ cells.The current views believe that the epigenetic modification is responsible for the transformation of germ cell fate and maintenance of developmental potential.Therefore,once the stress factors lead to epigenetic modification of the paternal germ cells in a certain period,it reprogram the germ cells,which can further transmit the harm to the offspring or even multiple generations.However,the mechanism of reprogramming of germ cells caused by chronic paternal stress has not been fully elucidated.This article reviewed the harm of paternal chronic stress to the paternal itself and its offspring for multiple generations,and combined the latest research progress to explore the mechanism by which paternal chronic stress affects reprogramming of reproductive cells,with a view to provide more theoretical basis for paternal-originated diseases.

关 键 词：慢性应激 表观遗传修饰 生殖细胞重编程 

分 类 号：R339.2[医药卫生—人体生理学]