加强全程管理,提高移植肾长期存活率  

To improve long-term graft survival rate by comprehensive management in the whole process of kidney transplantation

作　　者：朱兰[1] 张雷 陈刚[1] Zhu Lan;Zhang Lei;Chen Gang(Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology/Key Laboratory of Organ Transplantation,Ministry of Education/Key Laboratory of Organ Transplantation,National Health Commission,Wuhan 430030,China;Department of Organ Transplantation,Changhai Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所器官移植教育部重点实验室国家卫生健康委员会器官移植重点实验室,武汉430030 [2]海军军医大学附属长海医院器官移植科,上海200433

出　　处：《中华医学杂志》2022年第26期1956-1958,共3页National Medical Journal of China

基　　金：白求恩公益基金会“共享阳光-重大疾病临床科研合作项目”(G-X-2019-0101)。

摘　　要：新生供者特异性抗体(dnDSA)介导的慢性活动性抗体介导排斥反应(caAMR)是引起后期移植肾功能丢失的主要原因,因缺乏特效手段而治疗棘手。通过肾移植全程管理,从预防dnDSA的产生、计划性监测dnDSA变化、及时明确病理诊断和尽早启动综合治疗着手,将有利于caAMR的防治和最终提高移植肾的长期存活率。Chronic active antibody-mediated rejection(caAMR)caused by de novo donor-specific antibodies(dnDSA)is the main risk factor of late allograft loss in kidney transplantation.The treatment remains difficult due to the lack of effective methods.Through comprehensive management pre and post kidney transplantation,which starts from the prevention of dnDSA generation,periodical monitoring of dnDSA,to timely implement of pathological diagnosis and early initiation of synthetical treatment,it will be beneficial to the prevention and treatment of caAMR and ultimately improve the long-term survival of the renal graft.

关 键 词：肾移植 供者特异性抗体 抗体介导排斥反应 长期存活 

分 类 号：R699.2[医药卫生—泌尿科学]