中药联合甲状腺素替代疗法对甲减患者炎症因子、脂肪因子水平及甲状腺体积的影响  

Effects of traditional Chinese medicine combined with thyroxine replacement therapy on levels of inflammatory factors,adipokines and thyroid volume in patients with hypothyroidism

作　　者：杨青娟 张红爱 YANG Qingjuan;ZHANG Hong'ai(No.5 Internal Medicine Department,the Hospital of Chengcheng County,Weinan 715200;Endocrinology Department,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China)

机构地区：[1]陕西省渭南市澄城县医院内五科,陕西渭南715200 [2]安康市中医医院内分泌科,陕西安康725000

出　　处：《临床医学研究与实践》2022年第24期132-135,共4页Clinical Research and Practice

摘　　要：目的 探讨中药联合甲状腺素替代疗法对甲减患者炎症因子、脂肪因子水平及甲状腺体积的影响。方法 选择2017年8月至2020年6月我院收治的160例甲减患者作为研究对象,根据随机抽签法将其分为对照组和观察组,各80例。对照组行甲状腺素替代疗法,观察组在对照组基础上行养阴清热消瘿方治疗。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的游离三碘甲状腺原氨酸(FT_(3))、游离四碘甲状腺原氨酸(FT_(4))水平比较,差异无统计学意义(P>0.05);治疗后,两组的FT_(3)、FT_(4)水平高于治疗前,差异具有统计学意义(P<0.05);治疗后,观察组的FT_(3)、FT_(4)水平高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)水平比较,差异无统计学意义(P>0.05);治疗后,两组的hs-CRP、IL-1β水平低于治疗前,差异具有统计学意义(P<0.05);治疗后,观察组的hs-CRP、IL-1β水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的脂联素(ADP)水平及甲状腺体积比较,差异无统计学意义(P>0.05);治疗后,两组的ADP水平高于治疗前,甲状腺体积小于治疗前,差异具有统计学意义(P<0.05);治疗后,观察组的ADP水平高于对照组,甲状腺体积低于对照组,差异具有统计学意义(P<0.05)。结论 中药联合甲状腺素替代疗法治疗甲减的效果显著,有利于改善患者的FT_(3)和FT_(4)水平,抑制炎症因子的释放,缩小甲状腺体积。Objective To investigate the effects of traditional Chinese medicine combined with thyroxine replacement therapy on levels of inflammatory factors, adipokines and thyroid volume in patients with hypothyroidism. Methods One hundred and sixty patients with hypothyroidism admitted in our hospital from August 2017 to June 2020 were selected as the research objects. According to the random lottery method, the patients were divided into control group and observation group, with 80 cases in each group. The control group was treated with thyroxine replacement therapy, and the observation group was treated with Yangyin Qingre Xiaoying recipe on the basis of the control group. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment of the observation group was higher than that of the control group, and the difference was statistically significant(P <0.05). Before treatment, there were no significant differences in the levels of free triiodothyronine(FT) and free tetraiodothyronine(FT) between the two groups(P>0.05);after treatment, the levels of FTand FTin the two groups were higher than those before treatment, and the differences were statistically significant(P<0.05);after treatment, the levels of FTand FTin the observation group were higher than those in the control group, and the differences were statistically significant(P <0.05). Before treatment, there were no significant differences in the levels of high-sensitivity C-reactive protein(hs-CRP) and interleukin-1β(IL-1β) between the two groups(P>0.05);after treatment, the levels of hs-CRP and IL-1β in the two groups were lower than those before treatment, and the differences were statistically significant(P<0.05);after treatment, the levels of hs-CRP and IL-1β in the observation group were lower than those in the control group, and the differences were statistically significant(P <0.05).Before treatment, there were no significant difference in the adiponectin(ADP) level and thyroid volume between the two groups(P>0.05

关 键 词：甲状腺素替代疗法 养阴清热消瘿方 左甲状腺素钠 甲状腺功能减退 炎症因子 甲状腺体积 

分 类 号：R259[医药卫生—中西医结合]