Bcl-6对滤泡辅助性T细胞的调控作用及机制进展  

Research progress on the function and molecular regulation of Bcl-6 in follicular helper T cells

作　　者：何岚[1] 王猛 姜浩[3] HE Lan;WANG Meng;JIANG Hao(School of Biomedical Sciences,Hunan Provincial Key Laboratory of Medical Virology,Hunan University,Changsha 410012,China;Institut Pasteur of Shanghai,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;School of Life Sciences,Central South University,Changsha 410006,China)

机构地区：[1]湖南大学生命医学交叉研究院,医学病毒学湖南省重点实验室,长沙410012 [2]中国科学院上海巴斯德研究所,上海200031 [3]中南大学生命科学学院,长沙410006

出　　处：《华中师范大学学报（自然科学版）》2022年第4期670-675,共6页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金青年基金项目(32000622);湖南省自然科学基金青年项目(2021JJ40052);长沙市2020年度自然科学基金项目(kq2007042)。

摘　　要：Bcl-6是滤泡辅助性T细胞(Tfh)的亚群决定转录因子,在Tfh细胞分化和功能调节过程中发挥关键作用.Bcl-6调控Tfh细胞的分子机制及其受到的精密分子调控受到广泛研究,近年来已取得了一定的进展.该文回顾了Bcl-6被鉴定为Tfh细胞亚群转录决定因子的研究历程,总结Bcl-6在Tfh细胞中的功能,综述Tfh细胞调控Bcl-6表达机制的研究进展,并对Bcl-6研究中的潜在问题和未来研究方向进行了展望.Bcl-6 is the master regulator of follicular helper T cells(Tfh), which plays a key role in the differentiation and functional regulation of Tfh cells. The specific mechanisms of Bcl-6 regulation of Tfh cells and its precise molecular regulation have been extensively studied. At present, considerable progress has been made. In this paper the research history of Bcl-6 being identified as the master regulator of Tfh is reviewed, and the functions of Bcl-6 in Tfh cells and the research progress of mechanisms of Bcl-6 regulation in Tfh are summarized. The potential problems and future research directions of Bcl-6 are prospected.

关 键 词：BCL-6 滤泡辅助性T细胞 CD4+T细胞 T细胞分化 

分 类 号：Q291[生物学—细胞生物学]