噻托溴铵联合沙美特罗替卡松对COPD急性加重期患者肺功能及CRP、PCT水平的影响  

Effects of Tiotropium Bromide Combined with Salmeterol and Ficasone on Pulmonary Function and CRP and PCT Levels in Patients with Acute Exacerbation of COPD

作　　者：田甜 TIAN Tian(Department of Pharmacy,Guangrao County Hospital of Traditional Chinese Medicine,Dongying,Shandong Province,257300 China)

机构地区：[1]广饶县中医院药剂科,山东东营257300

出　　处：《系统医学》2022年第11期185-188,193,共5页Systems Medicine

摘　　要：目的探讨噻托溴铵联合沙美特罗替卡松对慢性阻塞性肺疾病(Chronic obstructive pulmonary dis⁃ease,COPD)急性加重期患者肺功能及CRP、PCT水平的影响。方法选取2020年5月-2021年5月广饶县中医院COPD急性加重期患者82例,采用交替分组法将患者分为两组,各41例。常规组予以患者噻托溴铵,测试组给予沙美特罗替卡松联合噻托溴铵方案治疗。对比不同方案临床治疗价值。结果干预后,测试组患者降钙素原(PCT)(0.24±0.02)μg/mL、C反应蛋白(CRP)(48.55±4.24)ng/mL指标均低于常规组PCT(0.58±0.07)μg/mL、CRP(72.71±6.41)ng/mL,差异有统计学意义(t=29.904、20.129,P<0.05)。干预后,测试组患者的肿瘤坏死因子-α与白介素-6指标均低于常规组,差异有统计学意义(P<0.05)。干预后,测试组患者用力肺活量、第1秒用力呼气容积、第1秒用力呼出量/用力肺活量比值均高于常规组,差异有统计学意义(P<0.05)。结论予以COPD急性加重期患者应用噻托溴铵联合沙美特罗替卡松方案进行干预,可以积极改善患者肺功能及CRP、PCT水平。Objective To investigate the effect of tiotropium bromide combined with salmeterol and ficasone on pul⁃monary function and CRP and PCT levels in patients with acute exacerbation of COPD.Methods A total of 82 pa⁃tients with acute exacerbation of COPD in Guangrao County Hospital of Traditional Chinese Medicine from May 2020 to May 2021 were selected,and the patients were divided into two groups by alternate grouping method,with 41 cases in each group.The routine group was given tiotropium bromide,and the test group was given salmeterol fica⁃sone combined with tiotropium bromide regimen.Compared the clinical therapeutic value of different regimens.Results After intervention,the procalcitonin(PCT)(0.24±0.02)μg/mL and C-reactive protein(CRP)(48.55±4.24)ng/mL indexes of the patients in the test group were lower than those in the routine group(0.58±0.07)μg/mL,CRP(72.71±6.41)ng/mL,the difference was statistically significant(t=29.904,20.129,P<0.05).After intervention,the levels of tumor necrosis factor-αand interleukin-6 in the test group were lower than those in the routine group,and the difference was statistically significant(P<0.05).After intervention,the forced vital capacity,forced expira⁃tory volume in 1 second,forced expiratory volume in 1 second/forced vital capacity ratio of the test group were higher than those in the routine group,and the differences were statistically significant(P<0.05).Conclusion The interven⁃tion of tiotropium bromide combined with salmeterol and ficasone in patients with acute exacerbation of COPD has a positive effect on improving the pulmonary function,CRP and PCT levels of patients.

关 键 词：沙美特罗替卡松 噻托溴铵 急性加重期 COPD 肺功能 

分 类 号：R4[医药卫生—临床医学]