维持性血液透析患者不宁腿综合征的影响因素  

Influencing factors of restless legs syndrome in maintenance hemodialysis patients

作　　者：张蓝月 田秀珣 雷艳[1] 王晓华[1] 刘洋[1] 吴建华 李金红 薛志强[3] 谢敏妍 胡明亮 段文娟[6] 郑智华[1] ZHANG Lanyue;TIAN Xiuxun;LEI Yan;WANG Xiaohua;LIU Yang;WU Jianhua;LI Jinhong;XUE Zhiqiang;XIE Minyan;HU Mingliang;DUAN Wenjuan;ZHENG Zhihua(Nephrology,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzheng 518107,China;Nephrology,Hui Ya Hospital of The First Affiliated Hospital,Sun Yat-sen University,Huizhou 516081,China;Nephrology,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan 511518,China;Nephrology,Guangzhou Panyu Central Hospital,Guangzhou 511400,China;Nephrology,Longhua People's Hospital,Shenzhen 518109,China;Nephrology,The East Division of The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510700,China)

机构地区：[1]中山大学附属第七医院肾内科,深圳518107 [2]中山大学附属第一医院惠亚医院肾内科 [3]广州医科大学附属第六医院肾内科 [4]广东省广州市番禺中心医院肾内科 [5]广东省深圳市龙华人民医院肾内科 [6]中山大学附属第一医院东院肾内科

出　　处：《肾脏病与透析肾移植杂志》2022年第3期244-249,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：深圳市科创委基金(JCYJ20180307150634856);深圳市科创委基金(JSGG20180703155802047)。

摘　　要：目的:探讨维持性血液透析(MHD)患者不宁腿综合征(RLS)的患病情况及其影响因素。方法:本研究为多中心横断面研究,将2020年7月至2020年11月在珠三角不同地区的6个透析中心符合纳入标准的MHD患者作为研究对象,根据国际RLS研究组织的诊断标准将患者分为RLS组和非RLS组。分析患者一般资料、临床基线数据、原发病及药物治疗情况等。结果:本研究共入组了527例患者,其中男性54.6%,中位年龄57.0(47.0,67.0)岁。RLS患者38例(7.2%),其中男性57.9%,中位年龄54.0(45.0,61.0)岁。与非RLS组相比,RLS组患者血磷(P=0.005)和透析前尿素氮(P=0.008)水平明显升高,以高血压肾损害为原发病的比例(P=0.005)及镇静安眠类药物的服用比例高(P=0.002)。二元Logistic回归分析结果提示,血磷(P=0.013)和高血压肾损害(P=0.008)是MHD患者RLS的独立危险因素。结论:RLS是MHD患者的重要并发症,高血磷水平及高血压肾损害可能促进其RLS发生。Objective:To investigate the prevalence and influencing factors of restless legs syndrome(RLS) in maintenance hemodialysis(MHD) patients. Methodology:This is a multi-center cross-sectional study. From July 2020 to November 2020, MHD patients who met the inclusion criteria covering 6 dialysis centers in different regions of the Pearl River Delta were chosen as subjects, then they were divided into RLS group and non-RLS group according to the diagnostic criteria of International Restless Legs Syndrome Study Group(IRLSSG). Patients’ general information, clinical baseline data, primary disease and medication were analyzed. Results:A total of 527 patients were enrolled, of whom 54.6% were male, with a median age of 57.0(47.0, 67.0) years. The prevalence of RLS were 7.2%, 57.9% were male, and the median age was 54.0(45.0, 61.0) years. Compared with the non-RLS group, the blood phosphorus(P=0.005) and pre-dialysis urea nitrogen(P=0.008) level in the RLS group were significantly increased, the proportion of hypertensive renal damage as the primary disease(P=0.005) and the use of sedatives and hypnotics(P=0.002) was also significantly higher. Binary Logistic regression analysis demonstrated that blood phosphorus level(P=0.013) and hypertensive renal damage(P=0.008) were independent risk factors for RLS in MHD patients. Conclusion:RLS is an important complication of MHD patients, high blood phosphate levels and hypertensive renal damage may promote the occurrence of it.

关 键 词：维持性血液透析 不宁腿综合征 血磷 高血压肾损害 

分 类 号：R692.5[医药卫生—泌尿科学]