富血小板血浆肌筋膜内注射治疗带状疱疹后神经痛疗效分析  

Analysis of Efficacy of Platelet-Rich Plasma Intramusfascial Injection of Shingpetic Neuralgia

作　　者：孔维宽 王森立 朱红 台杰[1] 刘俊娥[1] 付丽娟 王世军 KONG Weikuan;WANG Senli;ZHU Hong;TAI Jie;LIU Jun’e;FU Lijuan;WANG Shijun(Liaocheng Second People’s Hospital,Linqing 252600,Shandong China;Qilu Hospital of Shandong University Dezhou Hospital,Dezhou 253000,Shandong China)

机构地区：[1]山东聊城市第二人民医院,山东临清252600 [2]山东大学齐鲁医院德州医院

出　　处：《中国中医骨伤科杂志》2022年第7期57-60,共4页Chinese Journal of Traditional Medical Traumatology & Orthopedics

摘　　要：目的:分析富血小板血浆(PRP)肌筋膜内注射治疗带状疱疹后神经痛(PHN)的疗效。方法:选取2019年1月至2021年12月收治的60例老年胸腰段PHN患者,所有患者均接受肌筋膜内注射PRP治疗。记录所有患者的治疗疗效和不良反应发生情况,同时比较治疗前后的疼痛数字评分(NRS)、匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)及抑郁自评量表(SDS)等量表评分,以及血清疼痛介质水平。结果:所有患者的治疗总有效率为93.33%,不良反应总发生率为18.33%。随访3个月,治疗后1个月和3个月,所有患者的NRS和PSQI评分均明显低于治疗前,差异有统计学意义(P<0.05);治疗后3个月,所有患者的SAS和SDS评分均明显低于治疗前,差异有统计学意义(P<0.05),血清β-EP、NT水平均明显高于治疗前,差异有统计学意义(P<0.05),血清CGRP、VGF等水平均明显低于治疗前,差异有统计学意义(P<0.05)。结论:PRP肌筋膜内注射治疗PHN患者疗效显著,能明显减轻疼痛程度,提升睡眠质量,改善患者情绪状态,且治疗安全性高,值得临床推广应用。Objective:To study the efficacy of platelet-rich plasma intramusfascial injection on the treatment of posshingles neuralgia.Methods:60 elderly patients with thoracolumbar posterior herpes zoster neuralgia admitted in the pain department from January 2019 to December 2021 were selected.All patients received intramuscular injection of platelet-rich plasma.Treatment efficacy and adverse efficacy were recorded for all patients,including pain number score(NRS),PSQI,anxiety(SAS),and depression(SDS),and serum pain media levels.Results:The total treatment response rate was 93.33%,and the total incidence of adverse efficacy was 18.33%.At 3 months of follow-up,NRS and PSQI scores were significantly lower(P<0.05),SAS and SDS(P<0.05),and serum β-EP and NT levels were significantly higher than before treatment(P<0.05),and serum CGRP and VGF levels were significantly lower than before treatment(P<0.05).Conclusion:PRP intramuscular membrane injection is very effective in treating PHN patients,which can significantly reduce the pain degree,improve the sleep quality,improve the emotional state of patients,and has high treatment safety,which is worthy of clinical promotion.

关 键 词：富血小板血浆 肌筋膜内注射 带状疱疹 神经痛 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]