基于隐形眼镜的药物输送系统及其在眼前节疾病治疗中的应用  

Drug delivery system based on contact lenses and its application in the treatment of anterior segment diseases

作　　者：王烽 邵毅[2] Wang Feng;Shao Yi(Department of Ophthalmology,Meizhou Pepole's Hospital,Guangdong 514000,China;Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]广东省梅州市人民医院眼科,514000 [2]南昌大学第一附属医院眼科,330006

出　　处：《国际眼科纵览》2022年第3期236-241,共6页International Review of Ophthalmology

基　　金：国家自然科学基金(82160195);中央引导地方科技发展资金(20211ZDG02003);江西省重点研发项目(20181BBG700004,20203BBG73059);广东省梅州市人民医院科研培育项目(PY-2021060)。

摘　　要：滴眼液用于治疗眼前节疾病有许多局限性,如生物利用度低、剂量要求高和患者依从性差。隐形眼镜直接定位于眼表,因此基于隐形眼镜装载常规药物被用于探索治疗眼前节疾病的可行性和潜力,通过诸如简单浸泡、包含载药胶体纳米颗粒或分子印迹等技术将药物掺入到隐形眼镜中。无论使用何种技术,隐形眼镜的关键特性保持不变,如透明度和透氧性。基于隐形眼镜的药物输送系统能有效预防和控制眼表感染、促进角膜损伤愈合、治疗过敏性结膜炎、改善干眼症状,降低眼压,为眼前节疾病的治疗提供新的途径。Eye drop solutions are widely used by the ophthalmologist to treat the anterior segment eye diseases.However,eye drop solutions have many limitations including low bioavailability,high dose requirements,and poor patient compliance.Contact lenses are used to deliver the ocular drugs with high ocular bioavailability due to their immediate location to ocular surface.Based on the contact lenses,loading conventional drugs are used to explore the feasibility and potential to treat anterior eye disorders.Drug incorporated to the lens body is achieved with techniques,like simple soaking,inclusion of drug-loaded colloidal nanoparticles,or molecular imprinting.No matter what technique used,the key properties of the contact lens maintain unchanged,such as transparency and oxygen permeability.The drug delivery system based on contact lenses can effectively prevent and control ocular surface infection,promote corneal injury healing,treat allergic conjunctivitis,improve dry eye symptoms,and reduce intraocular pressure.It provides a new way for diagnosis and treatment of anterior segment disease.

关 键 词：隐形眼镜 眼前节疾病 药物传送系统 

分 类 号：R943[医药卫生—药剂学]