急性肾损伤的分子机制及中药的干预作用  

The Molecular Mechanism of Acute Kidney Injury and the Intervention Effect of Chinese Medicine

作　　者：程洁 周晔华 黄雅倩 王茂泓[3] 吴国庆[3] 宋卫国[3] 皮持衡[3] 黄勇[3] CHENG Jie;ZHOU Yehua;HUANG Yaqian;WANG Maohong;WU Guoqing;SONG Weiguo;PI Chiheng;HUANG Yong(Grade 2020 Graduate,Jiangxi University of Chinese Medicine,Jiangxi Province,Nanchang 330004,China;College of Science and Technology,Jiangxi University of Chinese Medicine,Jiangxi Province,Nanchang 330004,China;Department of Nephrology,Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Jiangxi Province,Nanchang 330004,China)

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西中医药大学科技学院,江西南昌330004 [3]江西中医药大学附属医院肾病科,江西南昌330006

出　　处：《光明中医》2022年第12期2142-2145,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：国家自然科学基金地区基金(No.82060849);国家自然科学基金地区基金(No.82160879);江西中医药管理局科技计划(No.2020A0296)。

摘　　要：急性肾损伤(Acute kidney injury,AKI)是多种因素所引起的急性肾实质损害,发病原因众多,机制复杂。此文对药物、脓毒血症、缺血再灌注损伤、大手术、横纹肌溶解等多种因素所导致AKI的分子机制进行综述,并对近年来中药及其有效成分治疗AKI的进展进行总结,旨为AKI的治疗提供有价值的文献资料。Acute kidney injury(AKI)is an acute kidney parenchymal damage caused by a variety of factors,with many causes and complex mechanisms.This article reviews the molecular mechanisms of AKI caused by various factors such as drugs,sepsis,ischemia-reperfusion injury,major surgery,rhabdomyolysis,and summarizes the progress of Chinese medicine and its active ingredients in the treatment of AKI in recent years.Aim to provide valuable literature for the treatment of AKI.

关 键 词：急性肾损伤 分子机制 中医药 

分 类 号：R277.5[医药卫生—中医学]