细胞焦亡与嗜神经病毒感染研究进展  

Research progress in the role of pyroptosis in neurotropic viruses infection

作　　者：李文娟 张凯 王春梅[2] LI Wen-juan;ZHANG Kai;WANG Chun-mei(School of Forensic and Laboratory Medicine,Jining Medical University,Jining 272067,Shandong,China;Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong)

机构地区：[1]济宁医学院法医学与医学检验学院,山东济宁272067 [2]济宁医学院神经生物学研究所

出　　处：《中国病原生物学杂志》2022年第7期857-861,867,共6页Journal of Pathogen Biology

基　　金：山东省自然基金项目(No.ZR2017LH056,ZR2020MHL136)。

摘　　要：细胞焦亡是一种伴随炎症反应的细胞程序性死亡方式。相比于细胞凋亡,细胞焦亡发生的更快,并会伴随着大量促炎症因子的释放。作为机体的重要免疫防御反应,细胞焦亡广泛参与感染性疾病、神经系统相关疾病等发生与发展。嗜神经病毒是一类对神经系统高度敏感的病毒,造成严重的中枢神经系统感染及并发症,病死率较高,但目前尚无有效治疗方法,因而受到广泛关注和研究。本文针对细胞焦亡在嗜神经病毒感染后炎症反应中发挥的作用及其机制进行综述,以期为后续研究深入阐释其具体机制、寻找抗病毒治疗的新靶点提供参考。Pyrophosis is a type of programmed cell death associated with inflammatory response.Pyrophosis,accompanied by release of a large number of pro-inflammatory factors,occurs faster than apoptosis.As an important immune defense response,pyrophosis is widely involved in the pathogenesis of infectious diseases and central nervous system infections.Neurotropic viruses,a group of viruses highly sensitive to the nervous system,could cause severe central nervous system infection and complications,with high mortality and lack of effective treatments yet.So it has been widely concerned and studied.This article reviews the function of pyrophosis in inflammatory response during neurotropic viruses infection,which would be beneficial on development of molecular pathogenesis and potential therapeutic drugs for antiviral infection treatment.

关 键 词：细胞焦亡 嗜神经病毒 神经系统感染 综述 

分 类 号：R37[医药卫生—病原生物学]