捏筋脉位疗法联合昂丹司琼预防顺铂所致恶心呕吐的临床研究  

Clinical Trial of Nie Jinmaiwei Massage Combined with Ondansetron for Chemotherapy-induced Nausea and Vomiting

作　　者：胡佳奇 陈顺泰 葛少侠 郑红刚[1] 花宝金[1] 张葛[1] HU Jiaqi;CHEN Shuntai;GE Shaoxia;ZHENG Honggang;HUA Baojin;ZHANG Ge(Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Ge's Kneading and Patting Therapy Workroom,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]中国中医科学院广安门医院肿瘤科,北京100053 [2]北京中医药大学研究生院,北京100029 [3]首都医科大学附属北京世纪坛医院葛氏捏筋拍打疗法工作室,北京100038

出　　处：《世界中医药》2022年第11期1515-1519,共5页World Chinese Medicine

基　　金：中国中医科学院广安门医院国家中医临床研究示范基地科研专项(2017S399);中国中医科学院优秀青年科技人才(创新类)培养专项(ZZ13-YQ-023);中国中医科学院科技创新工程项目(CI2021A01810,CI2021B009);国家中医药管理局中医药创新团队项目(ZYYCXTD-C-202205)。

摘　　要：目的:观察捏筋脉位疗法联合昂丹司琼预防顺铂所致恶心呕吐的疗效。方法:选取2019年4月至2020年1月中国中医科学院广安门医院肿瘤科收治的恶性肿瘤患者65例作为研究对象,根据入院顺序分为观察组(n=34)和对照组(n=31)。2组均给予静脉注射昂丹司琼,观察组给予捏筋脉位手法操作,对照组给予假按摩治疗。比较2组急性期、延迟期化疗所致呕吐控制率(CIV-CR)、化疗所致恶心控制率(CIN-CR)、完全控制率(CCR)、恶心严重程度、呕吐次数和生命质量(QoL)。结果:与对照组比较,观察组延迟性CIV-CR增加了27.8%(P=0.018),延迟性CIN-CR增加了27.4%(P=0.022),在延迟期的呕吐次数和恶心严重程度均显著下降(P=0.013;P=0.016)。但2组在急性期的CIV-CR(P=0.413)、CIN-CR(P=0.804)、CCR(P=0.152)、呕吐次数(P=0.308)和恶心严重程度(P=0.514),差异无统计学意义(P>0.05)。此外,捏筋脉位疗法改善了QoL(P=0.003),特别是在身体健康(P=0.001)和功能健康方面(P=0.023)。结论:捏筋脉位疗法联合昂丹司琼可改善延迟期的CIN-CR、CIV-CR、呕吐次数、恶心严重程度以及生合质量。Objective:To observe the clinical efficacy of Nie Jinmaiwei massage in preventing nausea and vomiting caused by cisplatin-included chemotherapy regimens.Methods:A total of 65 cases who received cisplatin-included chemotherapy regimens in Guang'anmen Hospital,China Academy of Chinese Medical Sciences from April 2019 to January 2020 were selected as research subjects.They were divided into observation group(n=34)and control group(n=31)according to the order of admission.In addition to intravenously administered ondansetron in both groups,the observation group was given Nie Jinmaiwei massage and the control group received sham massage treatment.The chemotherapy-induced vomiting control rate(CIV-CR),chemotherapy-induced nausea control rate(CIN-CR),complete control rate(CCR),severity of nausea,number of vomiting and quality of life(QoL)in acute and delayed phases were compared between the two groups.Results:Compared with the control group,the observation group had 27.8% increase in delayed CIV-CR(P=0.018),and 27.4% in delayed CIN-CR(P=0.022),and the number of vomiting and the severity of nausea were less in the observation group than those in the control group(1.1 vs.5.0,P=0.013;2.2 vs.3.9,P=0.016,respectively)in delayed phase.However,there were no differences in CIV-CR(P=0.413),CIN-CR(P=0.804),CCR(P=0.152),number of vomiting(P=0.308)and severity of nausea(P=0.514)in acute phase.Furthermore,Nie Jinmaiwei massage improved QoL(90.7 vs.83.5,P=0.003),especially in terms of functional well-being(24.1 vs.21.9,P=0.023).Conclusion:Nie Jinmaiwei massage combined with ondansetron for chemotherapy-included nausea and vomiting could improve CIN-CR,CIV-CR and QoL,and decrease the number of vomiting and the severity of nausea in delayed phase..

关 键 词：捏筋脉位 穴位 恶心 呕吐 昂丹司琼 化疗 顺铂 临床研究 

分 类 号：R273[医药卫生—中西医结合]