New Anti-HSV-1 Guaiane Lactone from Hainan Gorgonian Echinomuricea indomalaccensis  

作　　者：ZHOU Lifan CHEN Bao ZHANG Yahui ZHANG Xiuli LI Xin WANG Changyun 

机构地区：[1]Key Laboratory of Marine Drugs,the Ministry of Education of China,School of Medicine and Pharmacy,OceanUniversity of China,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China [3]Institute of Evolution&Marine Biodiversity,Ocean University of China,Qingdao 266003,China

出　　处：《Journal of Ocean University of China》2022年第4期965-968,共4页中国海洋大学学报（英文版）

基　　金：supported by the National Key Research and Development Program of China (No. 2018YF C0310900);the National Natural Science Foundation of China (No. 41830535);the Fundamental Research Funds for the Central Universities of China (No. 201962002);the Taishan Scholars Program, China

摘　　要：A new highly oxygenated guaiane lactone 5-epi-menverin C(1),along with four known compounds including one ses-quiterpene(2)and three steroids(3-5),were isolated from gorgonian Echinomuricea indomalaccensis which were collected from the South China Sea.Through anlyzing the NMR data and comparing with other reported compounds,their structures were determined.The absolute configuration of compound 1 was determined by comparing its experimental ECD with that obtained by calculation.In a bioassay in vitro,5-epi-menverin C(1)displayed antiviral activity against the HSV-1 virus with an inhibition rate of 69.2%(c=25μmol L−1).

关 键 词：gorgonian coral Echinomuricea indomalaccensis guaiane lactone anti-HSV-1 

分 类 号：R284.1[医药卫生—中药学]