可见光催化苯并噁唑与α-酮酸合成芳基苯并噁唑  

Synthesis of 2-Aryl Benzoxazoles from Benzoxazoles andα-Ketoic Acids by Photoredox Catalysis

作　　者：李亚东 吴鹏举 杨志勇 Li Yadong;Wu Pengju;Yang Zhiyong(Department of Chemical Engineering,Guizhou Institute of Technology,Guiyang 550003)

机构地区：[1]贵州理工学院化学工程学院,贵阳550003

出　　处：《有机化学》2022年第6期1770-1777,共8页Chinese Journal of Organic Chemistry

基　　金：贵州理工学院高层次人才启动(No.XJGC20180931);贵州省科技厅自然科学基金(Nos.QKHJZ20152060,QKH20167093,QKH Zhicheng[2017]2817,QKH Zhicheng[2018]2835)资助项目.

摘　　要：发展了一种高效的可见光催化合成2-芳基苯并噁唑的方法.与传统合成芳基苯并噁唑的方法相比,该方法反应条件温和,仅需要Eosin Y作为光催化剂,不需要任何其他金属催化剂.该反应副产物仅有CO_(2),后处理简单.在该反应条件下,含有不同取代基的苯并噁唑与α-酮酸都呈现出非常好的反应活性,能够合成一系列的芳基苯并噁唑.An efficient protocol for the synthesis of 2-aryl benzoxazoles via visible light-initiation has been developed.Compared with the traditional method for the synthesis of arylbenzoxazole,the reaction conditions of this method are mild,and only Eosin Y is needed as photocatalyst without any other metal catalyst.The purification of the desired product is easier because only CO_(2) is produced as the byproduct.Under the optimal reaction conditions,benzoxazole with different substituents andα-keto acids show very good reactivity and a series of arylbenzoxazoles can be synthesized.

关 键 词：可见光催化 2-芳基苯并噁唑 Α-酮酸 自由基反应 

分 类 号：O626[理学—有机化学]