可见光诱导活化烯烃的芳基氟烷基化反应  

Visible Light Induced Arylfluoroalkylation of Activated Alkenes

作　　者：李心灵 孟卫东[1] 徐修华[2] 黄焰根[1] Li Xinling;Meng Weidong;Xu Xiuhua;Huang Yan'gen(Key Laboratory of Science and Technology of Eco-Textiles,Ministry of Education,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620;Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]东华大学化学化工与生物工程学院生态纺织教育部重点实验室,上海201620 [2]中国科学院上海有机化学研究所有机氟化学重点实验室,上海200032

出　　处：《有机化学》2022年第6期1820-1830,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.2199121)资助项目.

摘　　要：含氟化合物在生物医药和材料领域有着广泛的应用,含氟化合物的合成方法学研究有着重要意义.以facIr(ppy)_(3)为光催化剂,可见光诱导下N-芳基-N-(芳基磺酰基)-2-甲基丙烯酰胺经氟烷基自由基加成、芳基迁移、脱砜基历程得到含氟烷基取代α-季碳中心结构的酰胺类化合物,反应条件温和,官能团兼容性良好.Fluorine-containing compounds have a wide range of applications in the fields of biomedicine and materials,and the development of synthetic methodology for fluorine-containing compounds is very important.Using fac-Ir(ppy)_(3) as catalyst,a wide variety of amides containing fluoroalkyl substitutedα-quaternary carbon center were prepared with N-aryl-N-(arylsulfonyl)-2-methyl acrylamides as starting materials by visible light induced cascade fluoroalkyl radical addition,aryl migration and desulfonylation.The reaction conditions are mild,and possess good functional group compatibility.

关 键 词：光催化 氟烷基化 芳基迁移 脱砜基 α-季碳中心 酰胺 

分 类 号：O621.25[理学—有机化学]