拟康定乌头中新的二萜生物碱及其拒食活性  

Diterpenoid Alkaloids from the Roots of Aconitum rockii and Their Antifeedant Activity

作　　者：黄帅[1,2] 冯宇明 任佳俐 杨传轮 陈琳[1,2] 周先礼[1,2] Huang Shuai;Feng Yuming;Ren Jiali;Yang Chuanlun;Chen Lin;Zhou Xianli(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031;Yibin Institute of Southwest,Jiaotong University,Yibin,Sichuan 644000;Chambroad Chemical Industry Research Institute Co.,Ltd,Binzhou,Shandong 256500)

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]西南交通大学宜宾研究院,四川宜宾644000 [3]黄河三角洲京博化工研究院有限公司,山东滨州256500

出　　处：《有机化学》2022年第6期1856-1862,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21807089);四川省应用基础项目(Nos.2021YJ0222,2020YJ0288);中央高校基本科研业务费专项(No.2682021CX085);教育部产学合作协同育人(Nos.202102414025,202102414026)资助项目.

摘　　要：为了发现更多结构新颖活性优异的二萜生物碱,继续对拟康定乌头化学成分进行研究,从其乙醇提取物中分离得到4个新化合物,通过HR-ESI-MS,1D和2D NMR等波谱技术鉴定了结构,分别为rockidines A~C(1~3)和rockisine A(4).同时考察了化合物1~4及前期分离得到的二萜生物碱(5~14)对甜菜夜蛾3龄幼虫的拒食活性,结果表明化合物13的拒食活性较好(EC_(50)=0.13 mg/cm^(2)).As part of our ongoing research program toward discovering structurally intriguing and biologically important diterpenoid alkaloids from the Aconitum genera,four new diterpenoid alkaloids,including three C_(19)-diterpenoid alkaloids(rockidines A~C)and one C_(20)-diterpenoid alkaloid(rockisine A)were isolated from the roots of Aconitum rockii Fletcher et Lauener in this paper.Their structures were elucidated on the basis of spectroscopic analyses(HR-ESI-MS,NMR and IR).All the new compounds 1~4,alone with ten known compounds 5~14 isolated in our previous work,were evaluated for their antifeedant activities,and compound 13 showed highly potent antifeedant activity with an effective concentration for 50%feeding reduction(EC_(50))at 0.13 mg/cm^(2).

关 键 词：毛茛科 拟康定乌头 二萜生物碱 拒食活性 

分 类 号：O629.3[理学—有机化学]